Results 61 to 70 of about 12,685,705 (296)

Optimization and Validation of Sound Absorption Performance of 10-Layer Gradient Compressed Porous Metal

Metals, 2019
Sound absorption performance of a porous metal can be improved by compression and optimal permutation, which is favorable to promote its application in noise reduction.
Fei Yang, Xinmin Shen, Panfeng Bai, Xiaonan Zhang, Zhizhong Li, Qin Yin   +5 more
doaj   +1 more source

Identification of Blood Biomarkers for Alzheimer's Disease Through Computational Prediction and Experimental Validation

Frontiers in Neurology, 2019
Background: Alzheimer's disease (AD) is the major cause of dementia in population aged over 65 years, accounting up to 70% dementia cases. However, validated peripheral biomarkers for AD diagnosis are not available up to present.
Fang Yao, Kao-yuan Zhang, Yan Zhang, Yi Guo, Aidong Li, Shifeng Xiao, Qiong Liu, Liming Shen, Jiazuan Ni   +8 more
semanticscholar   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Validation problems in computational fluid mechanics

Computer Assisted Methods in Engineering and Science, 2017
Recent developments in Computational Fluid Dynamics (CFD) increased interest in quantifying quality of the numerical models. One of the necessary steps is the so-called code validation procedure, an assessment of a numerical simulation by comparisons ...
Tomasz A. Kowalewski
doaj  

Investigation on the Material Failure in a Small Scale Automotive Camera Module via Root Cause Analysis and Experimental Validation

IEEE Access, 2019
Automotive camera modules are critical components for vision, detection, and recognition in an advanced driver assistance system. They usually consist of housing, a lens, a lens holder, a harness, seals, and printed circuit boards, which are assembled ...
Yongjun Pan, Wei Dai, Yue Xiong
doaj   +1 more source

QSAR-Based Virtual Screening of Natural Products Database for Identification of Potent Antimalarial Hits

Biomolecules, 2021
With about 400,000 annual deaths worldwide, malaria remains a public health burden in tropical and subtropical areas, especially in low-income countries.
Letícia Tiburcio Ferreira, Joyce V. B. Borba, José Teófilo Moreira-Filho, Aline Rimoldi, Carolina Horta Andrade, Fabio Trindade Maranhão Costa   +5 more
doaj   +1 more source

Experimental Localism and External Validity

Philosophy of Science, 2003
Experimental “localism” stresses the importance of context-specific knowledge, and the limitations of universal theories in science. I illustrate Latour's radical approach to localism and show that it has some unpalatable consequences, in particular the suggestion that problems of external validity (or how to generalize experimental results to ...
openaire   +3 more sources

Experimental Validation of a Three-Port Integrated Topology to Interface Electric Vehicles and Renewables With the Electrical Grid

IEEE Transactions on Industrial Informatics, 2018
This paper presents the analysis and the experimental validation of an off-board three-port integrated topology (TPIT) used to interface electric vehicles (EVs) and renewables from solar photovoltaic (PV) panels with the electrical power grid.
V. Monteiro, J. Pinto, J. Afonso
semanticscholar   +1 more source