Results 81 to 90 of about 12,685,705 (296)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Experimental validation of the Eclipse AAA algorithm [PDF]

Journal of Applied Clinical Medical Physics, 2007
The present study evaluates the performance of a newly released photon‐beam dose calculation algorithm that is incorporated into an established treatment planning system (TPS). We compared the analytical anisotropic algorithm (AAA) factory‐commissioned with “golden beam data” for Varian linear accelerators with measurements performed at two ...
Breitman, Karen, Rathee, Satyapal, Newcomb, Chris, Murray, Brad, Robinson, Don, Field, Colin, Warkentin, Heather, Connors, Sherry, MacKenzie, Marc, Dunscombe, Peter, Fallone, Gino   +10 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Multicriteria Sensitivity Analysis for Numerical Model Validation of Experimental Data

International Journal of Technology
Sensitivity analysis is a decisive step in experimental and numerical structural mechanics. The analysis of structural model quantifies the importance of each input parameter, potential interaction and effects on structural response.
Bobby Rio Indriyantho, Joko Purnomo, Purwanto, Marc Ottele, Ay Lie Han, Buntara Sthenly Gan   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

3D Topology Optimization of Fixed Offshore Structure and Experimental Validation

한국해양공학회지, 2020
In this study, we performed a three-dimensional (3D) topology optimization of a fixed offshore structure to enhance its structural stiffness. The proposed topology optimization is based on the solid isotropic material with penalization (SIMP) method ...
Hyun-Seok Kim, Hyun-Sung Kim, Byoungjae Park, Kangsu Lee   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A Novel Sensorless Control for Multiphase Induction Motor Drives Based on Singularly Perturbed Sliding Mode Observer-Experimental Validation

Applied Sciences, 2020
This paper aims to develop an innovative sensorless control approach for a five-phase induction motor (IM) drive. The operation principle of the sensorless scheme is based on the sliding mode theory, within which a sliding mode observer (SMO) estimates ...
Mahmoud A. Mossa, Hamdi Echeikh, Atif Iqbal, Ton Duc Do, Ameena Saad Al-Sumaiti   +4 more
doaj   +1 more source

Experimental Validation of a Novel Architecture Based on a Dual-Stage Converter for Off-Board Fast Battery Chargers of Electric Vehicles

IEEE Transactions on Vehicular Technology, 2017
The experimental validation of a novel architecture of an off-board, three-phase fast battery charger for electric vehicles (EVs) with innovative operation modes is presented in this paper.
V. Monteiro, J. Ferreira, Andrés A. Nogueiras Meléndez, C. Couto, J. Afonso   +4 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source