Results 71 to 80 of about 1,148,036 (286)
Artificial Intelligence and Machine Learning in Foot and Ankle Surgery: Current Concepts and Future Directions [PDF]
Journal of Foot and Ankle Surgery (Asia Pacific)Artificial intelligence (AI) technologies have permeated various medical fields, including orthopedics, where they offer advanced methods for diagnosis, treatment, and surgical intervention.
Amit Kumar +5 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Computers in Human Behavior: Artificial HumansEvaluating the surroundings to gain understanding, frame perspectives, and anticipate behavioral reactions is an inherent human trait. However, these continuous encounters are diverse and complex, posing challenges to their study and experimentation ...
Deepank Verma +2 more
doaj +1 more source
« Territoire zéro chômeur de longue durée » : les luttes d’interprétation d’un droit à l’emploi
La Nouvelle Revue du Travail, 2020 The “zero long-term unemployed territory” experiment relies on the idea that the resources dedicated to long-term unemployment (benefits, job-search support, etc.) can be redeployed to create new jobs. The project is also based on the idea that it is not
Mathieu Béraud, Jean-Pascal Higelé
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Varieties of Exploratory Experimentation in Nanotoxicology [PDF]
, 2008 There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways ...
Elliott, Kevin
core
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Experimentation in policy design: Insights from the building sector [PDF]
, 2015 The current article questions how experimentation in policy design plays out in practice. In particular, it is interested in understanding how the content and process of policy-design experiments affect their outcomes.
Van der Heijden, Jeroen
core +1 more source