Results 61 to 70 of about 485,070 (308)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Formal Grammar Instruction: Theoretical Aspects to Contemplate Its Teaching

Profile: Issues in Teachers' Professional Development, 2013
With the rise of new tendencies and methodologies in the English as a foreign language field, formal grammar instruction has become unnecessary during the last few years.
Cruz Corzo Carolina
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Pragmatic awareness of conversational implicatures and the usefulness of explicit instruction

Revista Nebrija de Linguistica Aplicada a la Enseñanza de Lenguas, 2015
The present study attempts to investigate the degree of pragmatic awareness of learners of English as a foreing language and also whether explicit instruction facilitates the learners’ interpretation of these implicatures.
Luciana María Cignetti, María Salomé Di Giuseppe   +1 more
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of explicit instruction in the acquisition of the present perfect O papel da instrução explícita na aquisição do presente perfect

Revista Brasileira de Linguística Aplicada, 2010
This paper aims at analyzing the role of explicit instruction in the learning of the Present Perfect by Brazilian university students in a formal setting.
Ingrid Finger, Fábio de Oliveira Vasques   +1 more
doaj   +1 more source

RANCANG BANGUN MULTIMEDIA PEMBELAJARAN INTERAKTIF BERBASIS GAME DENGAN MODEL PEMBELAJARAN EXPLICIT INSTRUCTION UNTUK MENINGKATKAN HASIL BELAJAR PADA MATA PELAJARAN BASIS DATA [PDF]

, 2017
Media pembelajaran merupakan salah satu komponen penting yang berpengaruh dalam proses pembelajaran karena media pembelajaran dapat menciptakan proses belajar- mengajar yang efektif. Proses pembelajaran sangat berpengaruh pada penerimaan siswa tentang
Amir, Ubaidillah
core  

Explicit Instruction in Core Reading Programs

The Elementary School Journal, 2014
AbstractThe purpose of this study was to conduct a content analysis of the types and occurrences of explicit instructional moves recommended for teaching five essentials of effective reading instruction in grades 1, 3, and 5 core reading program teachers’ editions in five widely marketed core reading programs.
Reutzel, D. Ray, Child, A., Jones, C.D., Clark, Sarah K.   +3 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source