Results 81 to 90 of about 485,070 (308)

L1 explicit instruction can improve L2 online and offline performance [PDF]

open access: yes, 2017
This study investigated the effectiveness of providing L1 explicit information (EI) with practice for making more accurate and faster interpretations of L2 French Imparfait (IMP). Two treatments were investigated: (a) “L2-only,” providing EI about the L2
Marsden, Emma, McManus, Kevin
core   +1 more source

Pragmatic competence and explicit instruction

open access: yesJournal of Pragmatics, 2013
Abstract The paper examines pragmatic competence re-defined ( Ifantidou, 2011a , Ifantidou, 2011b ) in terms of an open-ended array of pragmatically inferred implicatures rather than a fixed set of routines (e.g. speech acts) or isolated implicatures.
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

What are the ‘active ingredients’ of interventions targeting the public's engagement with antimicrobial resistance and how might they work? [PDF]

open access: yes, 2018
Objectives. Changing public awareness of antimicrobial resistance (AMR) represents a global public health priority. A systematic review of interventions that targeted public AMR awareness and associated behaviour was previously conducted.
Davis, Mark   +9 more
core   +4 more sources

Getting Explicit Instruction Right

open access: yes
There has been substantial public debate about the potentially deleterious effects of the long-run move to ``inquiry-based learning'' in which students are placed at the center of an educational journey and arrive at their own understanding of what is being taught.
Holden, Richard, Martinenghi, Fabio I.
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Effects of Multimedia Learning Combined With Strategy-Based Instruction on Vocabulary Learning and Strategy Use

open access: yesSAGE Open, 2019
The present study investigated the impact of multimedia-assisted explicit vocabulary learning strategy (VLS) instruction on foreign language learners’ strategy use and vocabulary learning.
Merak Rahimi, Atefeh Allahyari
doaj   +1 more source

Penerapan model pembelajaran explicit instruction untuk meningkatkan kemampuan menulis cerpen siswa kelas X SMA Negeri 5 Samarinda tahun pembelajaran 2012-2013 [PDF]

open access: yes, 2013
Penelitian ini bertujuan untuk meningkatkan hasil belajar bahasa Indonesia dengan menerapkan model pembelajaran explicit instruction pada materi menulis cerpen. Penelitian ini dilaksanakan pada semester genap tahun pembelajaran 2012/2013.
Lestari, Sri
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

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