Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Effects of Explicit Instruction of Expository Text Structure Incorporating Graphic Organizers on the Comprehension of Third-Grade Students [PDF]
, 2007 An important goal of education is to assist students to read and write expository text. Success in school, work, and society depends largely upon the ability to comprehend this type of text.
Newman, Lynn Michelle
core +1 more source
Pragmatic competence and explicit instruction
Journal of Pragmatics, 2013 Abstract The paper examines pragmatic competence re-defined ( Ifantidou, 2011a , Ifantidou, 2011b ) in terms of an open-ended array of pragmatically inferred implicatures rather than a fixed set of routines (e.g. speech acts) or isolated implicatures.
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Explicit strategy-instruction and the development of higher-order thinking skills in reading comprehension in a primary ESL classroom / Saw Beng Hong [PDF]
, 2012 Effective reading instruction in the early grades is the key to creating strong, competent readers. Hence, explicit strategy-instruction can be seen as a powerful student-centred approach to develop good learners to engage in divergent thinking.
Saw, Beng Hong
core
Effects of teacher explicit instruction in stance-taking on students' perceptions of stance and on their academic writing beliefs. [PDF]
Front Psychol, 2023 Zhang L, Zhang LJ, Xu TS.
europepmc +1 more source
The effect of explicit instructions in idea generation studies
Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 2018 AbstractIn inspiration and fixation experiments, example designs are often provided along with the instructions for how participants should treat them. However, research has not reached a consensus about the influence of such instructions, leading to difficulties in understanding how the examples and the instructions each affect idea generation.
Luis Arthur Vasconcelos +2 more
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Reading Comprehension Instruction of Effective Grades 5 and 6 Saint Lucian Teachers [PDF]
, 2008 This study set out primarily to investigate the nature of reading comprehension instruction in Saint Lucia, and to examine the explanations of teachers with regard to the factors that they perceive contribute to Grade 6 students' failure in the main idea
Sargusingh-Terrance, Lisa Merlene
core
, 2018 The internet has provided today’s middle years students with limitless, instantaneous information offering unprecedented educational benefits. Scholars have noted, however, that students frequently struggle to find information in such an overwhelming ...
Barton, Georgina, Morrison, Renee
core +1 more source