Results 91 to 100 of about 110,634 (264)
Solving Oscillatory Delay Differential Equations Using Block Hybrid Methods
Journal of Mathematics, 2018 A set of order condition for block explicit hybrid method up to order five is presented and, based on the order conditions, two-point block explicit hybrid method of order five for the approximation of special second order delay differential equations is
Sufia Zulfa Ahmad +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
SIMULATION ACCURACY STUDY ON THE STRENGTH TEST OF SEATBELTS ANCHORAGES BASED ON LS-DYNA
Jixie qiangdu, 2015 As to the strength test of seatbelts anchorages which is a quasi-static problem,through comparative analysis of central difference method（ explicit integration） and Newmark method（ implicit integration） in elastodynamics,this paper used explicit solution
ZHENG SongLin +3 more
doaj
MathematicsThe efficiency of various numerical methods for solving Huxley’s equation—which includes a diffusion term and a nonlinear reaction term—is investigated. Conventional explicit finite difference algorithms often suffer from severe stability limitations and
Husniddin Khayrullaev, Endre Kovács
doaj +1 more source
Altered awareness of action in Parkinson’s disease: evaluations by explicit and implicit measures
Scientific Reports, 2017 Deficits in the integration of motor prediction and its feedback have been reported in Parkinson’s disease. Conscious awareness of action is proposed to emerge under the integration of motor prediction and its feedback.
Naho Saito +7 more
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