Results 81 to 90 of about 110,634 (264)

A Novel Second-Order Explicit Integration Method for Nonlinear Ordinary Differential Equations in Dynamics

Mathematics
This paper introduces a new explicit integration method for second-order ordinary differential equations (ODEs) commonly encountered in engineering applications. Traditionally, these problems are solved either by reformulating them as first-order systems
Gorka Urkullu, Ibai Coria, Igor Fernández de Bustos, Haritz Uriarte   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Adaptivity in Crashworthiness Calculations

Shock and Vibration, 1993
h-Adaptive finite element methods for nonlinear transient analysis by explicit time integration are described. Examples are given of adaptive calculations for simple components and prototype calculations for a full car model.
Ted Belytschko, Sang-Ho Lee, I-Sheng Yeh, Jerry I. Lin, Chen-Shyh Tsay, James M. Kennedy   +5 more
doaj   +1 more source

Discrete-Time Implementation of Continuous Terminal Algorithm With Implicit-Euler Method

IEEE Access, 2019
This paper proposes an alternative implementation for a continuous terminal algorithm (CTA) proposed by Torres-Gonzalez et al. The original CTA is a continuous version of the twisting algorithm (TA), which mitigates the chattering by integrating the ...
Xiaogang Xiong, Wei Chen, Shanhai Jin, Shyam Kamal   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Partitioned Nonlinearity Soil–Structure Interaction Analysis for Nuclear Power Plant Structures with Pile Foundations

Buildings
Accurate seismic safety assessment of nuclear power plant (NPP) structures with pile foundations on soft soil sites requires consideration of soil nonlinearity and pile–soil–structure interaction (PSSI).
Lei Gao, Shaolin Chen
doaj   +1 more source

Understanding science teachers’ implementations of integrated STEM curricular units through a phenomenological multiple case study

International Journal of STEM Education, 2018
Background Current reforms in K-12 STEM education call for integration between science, technology, engineering, and mathematics (STEM). Such integration of STEM disciplines at the K-12 level offers students an opportunity to experience learning in real ...
Emily A. Dare, Joshua A. Ellis, Gillian H. Roehrig   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Numerical Solution of Anisotropic Diffusion with Localized Source Using Euler Scheme and Finite Element Method

Berkala Sainstek
This study investigates the numerical modeling of two-dimensional anisotropic diffusion processes involving a spatially localized and temporally limited energy or thermal source.
M. Ziaul Arif, Millatuz Zahroh, Sailah Ar Rizka   +2 more
doaj   +1 more source