Results 121 to 130 of about 140,450 (312)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Overview of Ka-band communications technology requirements for the space exploration initiative [PDF]
In the Space Exploration Initiative, Ka-band frequencies are likely to carry the bulk of the communications traffic both in the vicinity of and on the return links from the moon and Mars.
Miller, Edward F.
core +1 more source
The new Athena alpha particle X‐ray spectrometer for the Mars Exploration Rovers [PDF]
, 2003 R. Rieder +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Recent Efforts Enabling Martian Rotorcraft Missions [PDF]
The Mars Helicopter (MH), launching as a part of the Mars 2020 mission, will begin a new era of planetary exploration. Mars research has historically been conducted through landers, rovers, and satellites.
Johnson, Wayne R. +3 more
core +1 more source
MarsBots: Robotic Learning Module [PDF]
, 2006 This learning module offers hands-on, minds-on activities investigating the Martian environment and robotic technologies of space exploration. The learning module contains 16 national standards-based lessons designed to progress logically from learning ...
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Trajectory and navigation system design for robotic and piloted missions to Mars [PDF]
Future Mars exploration missions, both robotic and piloted, may utilize Earth to Mars transfer trajectories that are significantly different from one another, depending upon the type of mission being flown and the time period during which the flight ...
Matousek, S. E., Thurman, S. W.
core +1 more source