Results 191 to 200 of about 15,762 (228)

Exportin-1 is required for the maintenance of the planarian epidermal lineage

International Journal of Biological Macromolecules, 2019
Nucleocytoplasmic transport is essential for normal cellular function that mediates cargo transport from the cytoplasm to the nucleus. However, the mechanisms of nucleocytoplasmic transport that integrate stem cell development remain largely unknown. Since it has a large population of stem cells, the planarian flatworm is an ideal system for the study ...
Qingnan Tian, Jiaqian Liu
exaly   +3 more sources

Nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity.

New Phytologist, 2021
Exportin 1/XPO1 is an important nuclear export receptor that binds directly to cargo proteins and translocates the cargo proteins to the cytoplasm. To understand XPO1 protein functions during potyvirus infections, we investigated the nuclear export of ...
Ming-Zhen Zhang, Pan Gong, Lin-Hao Ge, Zhao-Yang Chang, Xiao-Fei Cheng, Xueping Zhou, Ai-Ming Wang, Fangfang Li   +7 more
semanticscholar   +1 more source

Exportin 1‐independent nuclear export of GAPDH

Cell Biology International, 2003
AbstractGlyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is a key enzyme of the glycolytic pathway. Recent studies have demonstrated an additional role in apoptosis: GAPDH is targeted to the nucleus during apoptotic signalling. This nuclear transport has also been observed in serum‐depleted cells, but it is reversible in fibroblasts, in contrast to ...
Hans-Dirk, Schmitz, Christine, Dutiné, Jürgen, Bereiter-Hahn   +2 more
openaire   +2 more sources

Structures of Importins and Exportins

2018
The karyopherin-β (Kap) family of nuclear transport receptors mediates the majority of nuclear-cytoplasmic transport of macromolecules, especially that of proteins. Kaps include importins that transport cargos into the nucleus, exportins that transport cargos out of the nucleus, and bidirectional Kaps that transport one set of cargos into the nucleus ...
Jordan Baumhardt, Yuh Min Chook
openaire   +1 more source

Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes.

International Immunopharmacology
Chronic obstructive pulmonary disease (COPD) poses a significant health threat characterized by lung inflammation primarily triggered by pulmonary monocytes.
Yuting Wu, Yanni Gou, Tao Wang, Ping Li, Yongqiang Li, Xing Lu, Wei-Feng Li, Zhi-Feng Liu   +7 more
semanticscholar   +1 more source

Exportin-Mediated Nuclear Export of Proteins and Ribonucleoproteins

2002
Protein export from the nucleus of eukaryotic cells serves three main purposes: (1) to remove factors that are only transiently required in the nucleus — transcriptional signaling molecules fall into this category; (2) to participate in RNA export — all RNAs that leave the nucleus, do so in complex with proteins; (3) to recycle import factors that have
Maarten, Fornerod, Mutsuhito, Ohno
openaire   +2 more sources

Hypertrophic lichenoid dermatitis immune‐related adverse event during combined immune checkpoint and exportin inhibitor therapy: A diagnostic pitfall for superficially invasive squamous cell carcinoma

Journal of cutaneous pathology, 2020
Immune checkpoint inhibitors (ICIs) for cancer treatment have revolutionized the field of medicine. However, an unintended but frequent consequence of ICI therapy is the development of cutaneous immune‐related adverse events (irAEs), such as lichenoid ...
M. Marques-Piubelli, M. Tetzlaff, P. Nagarajan, Taylor C. Duke, I. G. Glitza Oliva, Debora A. Ledesma, P. Aung, C. Torres-Cabala, Ignacio I. Wistuba, V. Prieto, Kelly C. Nelson, J. Curry   +11 more
semanticscholar   +1 more source

The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor

Archives of Insect Biochemistry and Physiology, 2010
AbstractNuclear localization of the ecdysteroid receptor (EcR) is increased in HeLa cells if exportin‐1 (CRM1), a predominant carrier for export of proteins and RNA from the nucleus into the cytoplasm, is knocked down by siRNA against exportin. However, knockdown of the small G protein Ran, which is essential for nuclear transport, leads to an arrest ...
Katarzyna, Betanska, Celine, Hönl, Margarethe, Spindler-Barth, Klaus-Dieter, Spindler   +3 more
openaire   +2 more sources

Importins and exportins: how to get in and out of the nucleus

Trends in Biochemical Sciences, 1998
Every minute, several million protein and RNA molecules must be transported between the cytoplasm and the nucleus of a eukaryotic cell. The characterization of mediators, receptors and accessory factors for different nuclear import and export pathways has provided a glimpse at the molecular machinery that is responsible for these trafficking events. It
openaire   +2 more sources

Phase 2 study of the Exportin 1 inhibitor selinexor in patients with recurrent gynecological malignancies.

Gynecologic Oncology, 2019
BACKGROUND Selinexor is an oral inhibitor of the nuclear export protein Exportin 1 (XPO1) with demonstrated antitumor activity in solid and hematological malignancies.
I. Vergote, B. Lund, U. Peen, Z. Umajuridze, M. Mau-Sørensen, A. Kranich, E. Van Nieuwenhuysen, C. Haslund, T. Nøttrup, Sileny Han, N. Concin, T. Unger, Y. Chai, N. Au, T. Rashal, A. Joshi, Marsha L. Crochiere, Y. Landesman, J. Shah, S. Shacham, M. Kauffman, M. Mirza   +21 more
semanticscholar   +1 more source