Results 211 to 220 of about 40,773 (278)

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, EarlyView.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

Targeting of the Gram-Negative Outer Membrane for Antibiotic Discovery and Potentiation. [PDF]

ACS Infect Dis
Draveny M, Masi M.
europepmc   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

REVS: A new open-source platform for high-resolution analysis of rodent wheel running behavior. [PDF]

J Neurosci Methods
Bonanno JL, O'Brien CF, Cafferty WBJ.
europepmc   +1 more source

Factors associated with the reproductive performance of ewes inseminated laparoscopically in England and Wales: A longitudinal study

Veterinary Record, EarlyView.
Abstract Background Laparoscopic intrauterine artificial insemination (Lap‐AI) is used in sheep genetic improvement programmes. However, the lambing rate (LR) (i.e., the proportion of inseminated ewes that lamb) following Lap‐AI is variable. Previously, one small UK study investigated factors associated with LR, but it did not adjust for dependencies ...
Mike J. Glover, Laura E. Green, Rachel Clifton   +2 more
wiley   +1 more source

A Patient with a Small Deletion Affecting Only Exon 1-Intron 1 of the <i>NXF5</i> Gene: Potential Evidence Supporting Its Role in Neurodevelopmental Disorders. [PDF]

Genes (Basel)
Tapia YY, Ciaccio C, Bacınoğlu MB, D'Arrigo S, Sciacca FL.   +4 more
europepmc   +1 more source

Estimating red deer Cervus elaphus population density using drones in a steep and rugged terrain

Wildlife Biology, EarlyView.
Precise and accurate information about population density, crucial for wildlife management, is difficult to obtain for elusive species living in dense forests or steep and inaccessible terrain. Using unmanned aerial vehicles (UAVs), we developed a method for obtaining absolute population estimates of ungulates living in steep, rugged, and partly ...
Julie Bommerlund, Torbjørn Ergon, Simon Filhol, Atle Mysterud   +3 more
wiley   +1 more source

Unveiling the metal-driven death: ferroptosis and cuproptosis in leukemia. [PDF]

Eur J Med Res
Chen Z, Yu J, Fu L, Fu J, Zhang Z, Hong P, Feng W.   +6 more
europepmc   +1 more source

Crystal structure and functional characterization of an Asp49 phospholipase A2 from the bushmaster (Lachesis muta)

Acta Crystallographica Section F, EarlyView.
The crystal structure of an Asp49 phospholipase A2 from L. muta is reported, revealing a tetrameric assembly, catalytic conservation and a polarized electrostatic surface potentially linked to membrane targeting.Snake‐venom phospholipases A2 (PLA2s) are small, structurally conserved enzymes that contribute significantly to the pathophysiology of ...
Noelia Erika Neyra Chama, Frey Francisco Romero Vargas, Eloy Condori Mamani, Jhon Antoni Vargas, Adriano Alves Furtado, Humberto D'Muniz Pereira, Ronald Demetrio Navarro Oviedo, Richard Charles Garratt, José Luis Javier Vega Ramírez, Diego Antonio Leonardo   +9 more
wiley   +1 more source

Two-component systems as potential therapeutic targets in <i>Neisseria</i> pathogenesis. [PDF]

Ann Med
Haldar T, Saroj SD.
europepmc   +1 more source