Results 51 to 60 of about 17,412 (233)

Perspective on using non-human primates in Exposome research

Ecotoxicology and Environmental Safety
The physiological and pathological changes in the human body caused by environmental pressures are collectively referred to as the Exposome. Human society is facing escalating environmental pollution, leading to a rising prevalence of associated diseases,
Qiu Tu, Gaojing Liu, Xiuyun Liu, Jiao Zhang, Wenxian Xiao, Longbao Lv, Bo Zhao   +6 more
doaj   +1 more source

Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population [PDF]

, 2012
Background: The ‘exposome’ represents the accumulation of all environmental exposures across a lifetime. Topdown strategies are required to assess something this comprehensive, and could transform our understanding of how environmental factors affect ...
Athersuch, Toby J., Bundy, Jacob G., Ellis, James K., Järup, Lars, Keun, Hector C., Pérez-Trujillo, Miriam, Singh, Rajinder, Spurgeon, David J., Svendsen, Claus, Teichert, Friederike, Thomas, Laura D.K.   +10 more
core   +4 more sources

Biomarkers intersect with the exposome [PDF]

Biomarkers, 2012
The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies.
openaire   +2 more sources

Positive association between dietary exposure to polybrominated diphenyl ethers and breast cancer risk in the French E3N cohort: The role of vegetable oil consumption

Environment International, 2022
Exposure to endocrine-disrupting chemicals, like Polybrominated diphenyl ethers (PBDEs), is suspected of playing a role in the occurrence of breast cancer.
Pauline Frenoy, Chloé Marques, Thibault Fiolet, German Cano-Sancho, Gianluca Severi, Francesca Romana Mancini   +5 more
doaj   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

The alcohol exposome

Alcohol
Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries.
Nousha H. Sabet, Todd A. Wyatt
openaire   +2 more sources

The Alzheimer's Disease Exposome

Alzheimer's & Dementia, 2019
AbstractIntroductionEnvironmental factors are poorly understood in the etiology of Alzheimer's disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD‐risk genetic variants.Results and DiscussionWe propose ...
Caleb E, Finch, Alexander M, Kulminski
openaire   +4 more sources

The human exposome unraveling the impact of environment on health: promise or reality?

Revista de Saúde Pública, 2019
Considering the innovative nature of the approach to human exposome, we present the state of the art of studies on exposome, and discuss current challenges and perspectives in this area.
Kelly Polido Kaneshiro Olympio, Fernanda Junqueira Salles, Ana Paula Sacone da Silva Ferreira, Elizeu Chiodi Pereira, Allan Santos de Oliveira, Isabelle Nogueira Leroux, Flávia Bosquê Alves Vieira   +6 more
doaj   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Extending participatory sensing to personal exposure using microscopic land use regression models [PDF]

, 2017
Personal exposure is sensitive to the personal features and behavior of the individual, and including interpersonal variability will improve the health and quality of life evaluations.
Botteldooren, Dick, Dekoninck, Luc, Panis, Luc Int   +2 more
core   +3 more sources