Results 151 to 160 of about 3,657 (262)

An evolutionary perspective for the exposome

Exposome
Abstract The exposome was proposed following the realization that most human diseases have an environmental rather than a genetic (hereditary) origin. Non-communicable diseases are, in fact, the consequence of multiple exposures that activate a sequence of stages in a multistage process that already starts in early life.
Paolo Vineis, Sonia Dagnino
openaire   +2 more sources

The role and mechanism of miR-425–3p regulating neuronal pyroptosis -mediated inorganic arsenic-induced generalized anxiety disorder

Ecotoxicology and Environmental Safety
Pyroptosis plays a critical role in the pathogenesis of mental disorders. However, its specific role and mechanism in arsenic (As)-induced generalized anxiety disorder (GAD) remain elusive.
Wei-Xing Lei, Lei Zhang, Jin-Li Chen, Gao-Hui Zheng, Lin-Nan Guo, Tao Jiang, Zi-yue Yin, Ming-Ying, Qi-ming Yu, Na Wang   +9 more
doaj   +1 more source

Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus

Scientific Reports
The aetiological mechanism of gestational diabetes mellitus (GDM) has still not been fully understood. The aim of this study was to explore the associations between functional genetic variants screened from a genome-wide association study (GWAS) and GDM ...
Gongchen Huang, Yan Sun, Ruiqi Li, Lei Mo, Qiulian Liang, Xiangyuan Yu   +5 more
doaj   +1 more source

A long and winding road: Culture change on data sharing in exposomics

Exposome
Data sharing requires cooperation from data generators (e.g., epidemiologists, lab investigators) and data users (e.g., epidemiologists, biostatisticians, computer scientists).
Robert O Wright, Konstantinos C. Makris, P. Natsiavas, Timothy R. Fennel, B. Rushing, Ander Wilson   +5 more
semanticscholar   +1 more source

Associations between the METS-IR index and cognitive function in community-dwelling Chinese middle-aged and older adult individuals: a cross-sectional study

Frontiers in Public Health
ObjectiveThe relationship between insulin resistance and cognitive function has long been a subject of interest, but the association between the metabolic syndrome-insulin resistance (METS-IR) index and cognitive impairment remains unclear.MethodsWe ...
Nian Jiang, Nian Jiang, Chenlu Ma, Chenlu Ma, Zhenning Feng, Zhenning Feng, Yongjun Tang, Yongjun Tang, Xiaolong Chen, Xiaolong Chen, Yingxu He, Yingxu He, Weiyi Pang, Weiyi Pang, Weiyi Pang   +14 more
doaj   +1 more source

Advancing Exposomic Research in Prenatal Respiratory Disease Programming

, 2022
Rosalind J. Wright
openalex   +2 more sources

IDSL.UFA assigns high confidence molecular formula annotations for untargeted LC/HRMS datasets in metabolomics and exposomics [PDF]

, 2022
‪Sadjad Fakouri Baygi‬, S. K. Banerjee, Praloy Chakraborty, Yashwant Kumar, Dinesh Kumar Barupal   +4 more
openalex   +1 more source

Commentary: Data Processing Thresholds for Abundance and Sparsity and Missed Biological Insights in an Untargeted Chemical Analysis of Blood Specimens for Exposomics

Frontiers in Public Health, 2022
Pekka Keski-Rahkonen, Oliver Robinson, Rossella Alfano, Rossella Alfano, Michelle Plusquin, Augustin Scalbert   +5 more
doaj   +1 more source

Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload

Ecotoxicology and Environmental Safety
Manganese (Mn) is an essential trace element for maintaining bodily functions. Excessive exposure to Mn can pose serious health risks to humans and animals, particularly to the nervous system.
Changyong Wang, Hongyan Zhao, Yaoyang Liu, Minghai Qu, Shanyu Lv, Guoguo He, Hongshuo Liang, Kemiao Chen, Lin Yang, Yonghua He, Chaoyan Ou   +10 more
doaj   +1 more source

Only one health, and so many omics [PDF]

, 2015

core   +1 more source