Results 141 to 150 of about 3,965,960 (305)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Residential Population Generator (RPGen): Parameterization of Residential, Demographic, and Physiological Data to Model Intraindividual Exposure, Dose, and Risk. [PDF]

Toxics, 2021
East A, Dawson D, Glen G, Isaacs K, Dionisio K, Price PS, Hubal EAC, Vallero DA.   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Airborne microplastics and plastic additives in a school environment: identification, quantification, and associated inhalation risks

Environment International
Indoor and outdoor air pollution is related to adverse human health effects, especially in children due to their ongoing physical development. This study assesses airborne microplastics (MP) concentrations and associated inhalation risks in a school in ...
Ana Torres-Agullo, Angeliki Karanasiou, Isabella Charres, Célia Alves, Silvia Lacorte   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

COVID-19 virus released from larynx might cause a higher exposure dose in indoor environment. [PDF]

Environ Res, 2021
Wu J, Weng W.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Low-dose pulmonary CT angiography: reduced radiation exposure and iodine load at low tube kilovoltage

, 2010
CT pulmonary angiography is the currently accepted standard in ruling out acute pulmonary embolism. Issues of radiation dose received by patients via CT have been extensively disputed by radiologists and reported by the media.
Peter Vock, Vock, Peter, Zsolt Szucs-Farkas, Sebastian T Schindera, Schindera, Sebastian Tobias, Szücs Farkas, Zsolt   +5 more
core   +1 more source

Direct measurement of radiation exposure dose to individual organs during diagnostic computed tomography examination. [PDF]

Sci Rep, 2021
Yamashita K, Higashino K, Hayashi H, Takegami K, Hayashi F, Tsuruo Y, Sairyo K.   +6 more
europepmc   +1 more source

DOSES ASSESSMENT OF POPULATION AT LONG-TERM PERIOD AFTER THE CHERNOBYL ACCIDENT

Радиационная гигиена, 2015
Republiccontaminated settlements had been developed. The results of the Whole Body measurements had been used as the basis for the model developing. The model for dose estimation is based on the classification of the settlements according to regional ...
N. G. Vlasova
doaj