Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Estimating the Effects of Lenght of Exposure to Traning Program: The Case of Job Corps [PDF]
Length of exposure to a training program is important in determining the labor market outcomes of participants. Employing methods to estimate the causal effects from continuous treatments, we provide insights regarding the effects of different lengths of
Arturo Gonzalez +3 more
core
Social factors and behavioural reactions to radon test outcomes underlie differences in radiation exposure dose, independent of household radon level. [PDF]
Sci Rep, 2022 Irvine JL +6 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Estimating previous exposure to arsenic for populations living in parts of Hungary, Romania and Slovakia [PDF]
, 2005 Arsenic Health Risk Assessment and Molecular Epidemiology (ASHRAM) is a large EU-funded case-control study looking at risk of cancer (bladder, kidney and skin) due to arsenic in drinking water.
Hough, RL, Fletcher, T, Leonardi, GS
core +1 more source
Long-Term Analysis of Internal Exposure Dose-Reduction Effects by Food Regulation and Food Item Contribution to Dose after the Fukushima Daiichi Nuclear Power Plant Accident. [PDF]
Foods, 2023 Osanai M +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Radiation Hormesis: Historical Perspective and Implications for Low-Dose Cancer Risk Assessment
, 2010 Current guidelines for limiting exposure of humans to ionizing radiation are based on the linear-no-threshold (LNT) hypothesis for radiation carcinogenesis under which cancer risk increases linearly as the radiation dose increases.
Alexander M. Vaiserman +1 more
core +1 more source
Author Correction: Direct measurement of radiation exposure dose to individual organs during diagnostic computed tomography examination. [PDF]
Sci Rep, 2022 Yamashita K +6 more
europepmc +1 more source
Clinical and Translational ScienceRecent updates in clinical guidelines and health authority guidance documents have aimed to standardize best practices for assessing renal function; however, it remains unclear whether the pharmaceutical industry has fully adopted these recommendations ...
Noah Christopher Frazier +2 more
doaj +1 more source