Results 111 to 120 of about 3,965,960 (305)

Modeling dose-Response at Low dose: A Systems Biology Approach for Ionization Radiation

, 2010
For ionization radiation (IR) induced cancer, a linear non-threshold (LNT) model at very low doses is the default used by a number of national and international organizations and in regulatory law.
Paolo F. Ricci, Yuchao Zhao
core   +1 more source

Evaluation of basic characteristics of 3-mm dose equivalent measuring instrument for evaluating lens exposure dose in radiotherapy. [PDF]

J Med Radiat Sci, 2023
Mori Y, Isobe T, Takei H, Miyazaki S, Kamizawa S, Tomita T, Kobayashi D, Sakurai H, Sakae T.   +8 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Induction Exposure Dose of Ipilimumab and Failure of Adjuvant Nivolumab Plus Ipilimumab in Melanoma. [PDF]

J Clin Oncol, 2023
Augustin RC, Luke JJ.
europepmc   +1 more source

MODERN PECULIARITIES OF THE MEDICAL EXPOSURE LEVELS FORMING OF THE TATARSTAN REPUBLIC POPULATION DURING X-RAY PROCEDURES IMPLEMENTATION

Радиационная гигиена, 2015
The purpose. The purpose of the investigation is an assessment of the peculiarities of forming and registration of the collective doses of patients and the population of the Tatarsatan Republic (RT) from medical exposure and the development of measures ...
S. A. Ryzhkin, S. I. Ivanov, M. A. Patjashina, R. K. Ismagilov, N. A. Akopova, S. V. Loginova, D. R. Nasybullin   +6 more
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

3D Nanoprinting Replication Enhancement Using a Simulation-Informed Analytical Model for Electron Beam Exposure Dose Compensation. [PDF]

ACS Omega, 2023
Fowlkes JD, Winkler R, Rack PD, Plank H.
europepmc   +1 more source

Benchmark dose profiles for bivariate exposures

Risk Analysis
AbstractWhile benchmark dose (BMD) methodology is well‐established for settings with a single exposure, these methods cannot easily handle multidimensional exposures with nonlinear effects. We propose a framework for BMD analysis to characterize the joint effect of a two‐dimensional exposure on a continuous outcome using a generalized additive model ...
Tugba Akkaya Hocagil, Louise M. Ryan, Richard J. Cook, Khue‐Dung Dang, R. Colin Carter, Gale A. Richardson, Nancy L. Day, Claire D. Coles, Heather Carmichael Olson, Sandra W. Jacobson, Joseph L. Jacobson   +10 more
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

ATSDR\u2019s Exposure-Dose Reconstruction Program program summary

The Agency for Toxic Substances and Disease Registry (ATSDR), a U.S. Public Health Service agency, established the Exposure-Dose Reconstruction Program (EDRP) in March 1993.

core