Results 201 to 210 of about 1,268,376 (267)

TRP channel expression patterns define molecular subtypes, prognosis, and therapeutic targets in gastric cancer. [PDF]

Front Immunol
Ding Z, Liu W, Li ZX, Cheng JQ, Deng C, Wang KW, Li LJ.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Developmental expression patterns of the FXR-IGF axis during early skeletal muscle growth in ducks. [PDF]

Poult Sci
Chen L, Wang X, Luo J, Wu L, Ma S, Mao T, Sun W, Li D, Zhao Y, Zhou F, Feng Y.   +10 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Transformer-based classification and interpretability of NR3C1 expression patterns in OSCC: Metabolic adaptation insights. [PDF]

J Oral Biol Craniofac Res
Yuwanati M, Yadalam PK, Mullainathan S.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

UBE2S and HIF1α expression patterns and stratified analysis reveal prognostic value in esophageal squamous cell carcinoma. [PDF]

PeerJ
Ma M, Li M, Lv Y, Zhang Y, Pang X, Ma Y.
europepmc   +1 more source

Background-Free Nanopore Decoding of microRNA Expression Patterns Using Circular Diagnostic DNA. [PDF]

Anal Chem
Emura S, Takeuchi N, Ohshima T, Satomura K, Kawano R.   +4 more
europepmc   +1 more source

Identification of Ubiquitin Genes and Their Expression Patterns in <i>Pinus massoniana</i> Under Infection Stress from the Pinewood Nematode. [PDF]

Plants (Basel)
Chen Q, Zhou H, Hu S, Zhou Z, Liu B, Gao K, Ji K, Liu Q.   +7 more
europepmc   +1 more source