Results 11 to 20 of about 135,054 (291)

A mega-analysis of expression quantitative trait loci in retinal tissue. [PDF]

PLoS Genetics, 2020
Significant association signals from genome-wide association studies (GWAS) point to genomic regions of interest. However, for most loci the causative genetic variant remains undefined.
Tobias Strunz, Christina Kiel, Felix Grassmann, Rinki Ratnapriya, Madeline Kwicklis, Marcus Karlstetter, Sascha Fauser, Nicole Arend, Anand Swaroop, Thomas Langmann, Armin Wolf, Bernhard H F Weber   +11 more
doaj   +2 more sources

Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes [PDF]

, 2012
Aims/hypothesisWhile genome-wide association studies (GWASs) have been successful in identifying novel variants associated with various diseases, it has been much more difficult to determine the biological mechanisms underlying these associations ...
Han-Mei-Xuan Kang, Xia Yang, R. Chen, Bin Zhang, Erik Corona, Eric E. Schadt, Atul J. Butte   +6 more
openalex   +5 more sources

Biological, clinical and population relevance of 95 loci for blood lipids [PDF]

Nature, 2010
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic ...
Kiran Musunuru, Albert V. Smith, James P Pirruccello   +2 more
exaly   +2 more sources

Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes [PDF]

Nature Communications
Transcriptome-wide association study (TWAS) is a popular approach to dissect the functional consequence of disease associated non-coding variants. Most existing TWAS use bulk tissues and may not have the resolution to reveal cell-type specific target ...
Lida Wang, Chachrit Khunsriraksakul, Havell Markus, Dieyi Chen, Fan Zhang, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang. J. Liu, Bibo Jiang   +9 more
doaj   +2 more sources

Identifying cancer tissue-of-origin by a novel machine learning method based on expression quantitative trait loci. [PDF]

Front Oncol, 2022
Miao Y, Zhang X, Chen S, Zhou W, Xu D, Shi X, Li J, Tu J, Yuan X, Lv K, Tian G.   +10 more
europepmc   +3 more sources

Characterizing the Relationship between Expression Quantitative Trait Loci (eQTLs), DNA Methylation Quantitative Trait Loci (mQTLs), and Breast Cancer Risk Variants. [PDF]

Cancers (Basel)
Ho PJ, Khng A, Tan BK, Khor CC, Tan EY, Lim GH, Yuan JM, Tan SM, Chang X, Tan VKM, Sim X, Dorajoo R, Koh WP, Hartman M, Li J.   +14 more
europepmc   +3 more sources

Charactering the interaction between expression quantitative trait loci and Alzheimer's Disease Status [PDF]

Alzheimers Dement
Mews M, Mustafa Y, Wheeler N, Gu T, Gomez L, Adams L, Starks T, Cornejo‐Olivas M, Illanes‐Manrique M, Silva C, Feliciano‐Astacio B, Byrd G, Pericak‐Vance M, Haines J, Griswold A, Bush W.   +15 more
europepmc   +3 more sources

Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas

Cells, 2023
In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Géraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sébastien Jacques, Colin E. Murdoch, Francisco Miralles, Céline Méhats, Daniel Vaiman   +12 more
doaj   +1 more source

Expression quantitative trait loci associated with Nellore meat pH. [PDF]

, 2023
Genomic studies make it possible to identify polymorphisms associated with quantitative characteristics of economic interest, such as meat pH, a factor that influences meat ...
BEATRIZ, D. L., COUTINHO, L. L., GARCIA, I. S., REGITANO, L. C. de A., SILVA, T. R. da, SILVA-VIGNATO, B.   +5 more
core  

Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice

Journal of Lipid Research, 2011
To identify genetic loci influencing lipid levels, we performed quantitative trait loci (QTL) analysis between inbred mouse strains MRL/MpJ and SM/J, measuring triglyceride levels at 8 weeks of age in F2 mice fed a chow diet.
Magalie S. Leduc, Rachael S. Hageman, Ricardo A. Verdugo, Shirng-Wern Tsaih, Kenneth Walsh, Gary A. Churchill, Beverly Paigen   +6 more
doaj   +1 more source