Results 11 to 20 of about 132,242 (193)

Expression quantitative trait loci are highly sensitive to cellular differentiation state [PDF]

PLoS Genetics, 2009
Blood cell development from multipotent hematopoietic stem cells to specialized blood cells is accompanied by drastic changes in gene expression for which the triggers remain mostly unknown.
A Gerrits, Albertina Ausema, Alice Gerrits, AR Whiteley, B Wang, Bert Dontje, Bruno M. Tesson, D Bryder, E Petretto, EC Forsberg, EE Schadt, EE Schadt, EJ Chesler, EJ Chesler, Ellen Weersing, G Dennis Jr, Gerald de Haan, Greg Gibson, HH Goring, J Wang, JD Storey, JJ Keurentjes, JL Peirce, JY Wu, KH Wang, L Bystrykh, Leonid V. Bystrykh, M Morley, MA West, MJ Anderson, MJ Kiel, MV Rockman, N Hubner, NB Ivanova, R Alberts, R Breitling, Rainer Breitling, RC Jansen, Ritsert C. Jansen, SA Monks, SM Chambers, V Emilsson, Xusheng Wang, Y Chen, Y Katoh, Y Li, Y Li, Y Liang, Yang Li   +48 more
core   +12 more sources

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients [PDF]

Frontiers in Molecular Neuroscience
IntroductionMetabolic syndrome (MetS) and Parkinson’s disease (PD) share common pathophysiological and molecular impairments related to high PD incidence in MetS patients.
Guenson Chevalier, Lucas Udovin, Matilde Otero-Losada, Sofia Bordet, Sofia Bordet, Santiago Perez-Lloret, Santiago Perez-Lloret, Francisco Capani, Francisco Capani   +8 more
doaj   +4 more sources

Multiple locus linkage analysis of genomewide expression in yeast. [PDF]

PLoS Biology, 2005
With the ability to measure thousands of related phenotypes from a single biological sample, it is now feasible to genetically dissect systems-level biological phenomena.
Akey, Joshua M, Kruglyak, Leonid, Storey, John D   +2 more
core   +7 more sources

A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci. [PDF]

PLoS Genetics, 2011
We conducted a comprehensive study of copy number variants (CNVs) well-tagged by SNPs (r(2)≥ 0.8) by analyzing their effect on gene expression and their association with disease susceptibility and other complex human traits.
Eric R Gamazon, Dan L Nicolae, Nancy J Cox   +2 more
doaj   +3 more sources

Integrating transcriptomic and genomic studies for the identification of expression quantitative trait loci associated with bovine paratuberculosis [PDF]

Frontiers in Veterinary Science
The study of the genetic basis underlying the host response to Mycobacterium avium subsp. paratuberculosis (MAP) is usually performed using genome-wide association studies (GWAS), which assess the individual association between genotyped markers ...
Gerard Badia-Bringué, Marta Alonso-Hearn   +1 more
doaj   +2 more sources

Genome-Wide Expression Quantitative Trait Loci Analysis Using Mixed Models [PDF]

Frontiers in Genetics, 2018
Expression quantitative trait loci (eQTLs) are important for understanding the genetic basis of cellular activities and complex phenotypes. Genome-wide eQTL analyses can be effectively conducted by employing a mixed model. The mixed model includes random
Chaeyoung Lee
doaj   +2 more sources

Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer [PDF]

BMC Genomics
Background Genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to DNA damage response (DDR). By analyzing expression quantitative trait loci (eQTL) upon cell stimulation (called exposure eQTL (e2QTL)) it ...
Jessica Bigge, Laura L. Koebbe, Ann-Sophie Giel, Dorothea Bornholdt, Benedikt Buerfent, Pouria Dasmeh, Alexander M. Zink, Carlo Maj, Johannes Schumacher   +8 more
doaj   +2 more sources

Placental expression quantitative trait loci in an East Asian population [PDF]

HGG Advances
Summary: Expression quantitative trait loci (eQTL) analysis measures the contribution of genetic variation in gene expression on complex traits. Although this methodology has been used to examine gene regulation in numerous human tissues, eQTL research ...
Jaeyong Choi, Seung Mi Lee, Errol R. Norwitz, Ji Hoi Kim, Young Mi Jung, Chan-Wook Park, Jong Kwan Jun, Dakyung Lee, Yongjoon Jin, Sookyung Kim, Bukyoung Cha, Joong Shin Park, Jong-Il Kim   +12 more
doaj   +2 more sources

Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes [PDF]

Arthritis Research & Therapy, 2021
Background We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-established genetic risk alleles ...
Yogita Ghodke-Puranik, Zhongbo Jin, Kip D. Zimmerman, Hannah C. Ainsworth, Wei Fan, Mark A. Jensen, Jessica M. Dorschner, Danielle M. Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Carl D. Langefeld, Timothy B. Niewold   +15 more
doaj   +2 more sources

Variable expression quantitative trait loci analysis of breast cancer risk variants [PDF]

Scientific Reports, 2021
Genome wide association studies (GWAS) have identified more than 180 variants associated with breast cancer risk, however the underlying functional mechanisms and biological pathways which confer disease susceptibility remain largely unknown.
George A. R. Wiggins, Michael A. Black, Anita Dunbier, Tony R. Merriman, John F. Pearson, Logan C. Walker   +5 more
doaj   +2 more sources