Results 21 to 30 of about 135,054 (291)

Expression quantitative trait loci (eQTL) mapping in Puerto Rican children. [PDF]

PLoS ONE, 2015
Expression quantitative trait loci (eQTL) have been identified using tissue or cell samples from diverse human populations, thus enhancing our understanding of regulation of gene expression.
Wei Chen, John M Brehm, Jerome Lin, Ting Wang, Erick Forno, Edna Acosta-Pérez, Nadia Boutaoui, Glorisa Canino, Juan C Celedón   +8 more
doaj   +1 more source

Expression quantitative trait loci analysis in plants [PDF]

, 2010
An expression Quantitative Trait Locus or eQTL is a chromosomal region that accounts for a proportion of the variation in abundance of a mRNA transcript observed between individuals in a genetic mapping population.
Chen, Xinwei, Druka, Arnis, Jiang, Ning, Kearsey, Mike, Luo, Zewei, Potokina, Elena, Waugh, Robbie   +6 more
core   +2 more sources

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken

G3: Genes, Genomes, Genetics, 2016
Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping.
Martin Johnsson, Kenneth B. Jonsson, Leif Andersson, Per Jensen, Dominic Wright   +4 more
doaj   +1 more source

Population differences in transcript-regulator expression quantitative trait loci.

PLoS ONE, 2012
Gene expression quantitative trait loci (eQTL) are useful for identifying single nucleotide polymorphisms (SNPs) associated with diseases. At times, a genetic variant may be associated with a master regulator involved in the manifestation of a disease ...
Pierre R Bushel, Ray McGovern, Liwen Liu, Oliver Hofmann, Ahsan Huda, Jun Lu, Winston Hide, Xihong Lin   +7 more
doaj   +1 more source

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Adeniran, I., Amuzu, A., Braund, P.S., Burton, P.R., Casas, J.-P., Day, I.N.M., Drenos, F., Eriksson, P., Folkersen, L., Gaunt, T.R., Hancox, J.C., Hingorani, A.D., Humphries, S.E., Kivimaki, M., Kumari, M., Lawlor, D.A., Macfarlane, P.W., Nelson, C.P., Samani, N.J., Shah, S., Talmud, P.J., Tobin, M.D., Tomaszewski, M., Whittaker, J., Zhang, H.   +24 more
core   +1 more source

A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. [PDF]

, 2018
Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. Here we perform an integrative analysis of 930 tumor whole genomes and matched transcriptomes, identifying a network of 193 ...
Bojorquez-Gomez, Ana, Carter, Hannah, Chen, Kevin, Farley, Emma K, Fraley, Stephanie I, Huang, Justin K, Ideker, Trey, Kreisberg, Jason F, Licon, Katherine, Melton, Collin, Olson, Katrina M, Sanchez, Kyle S, Shen, John Paul, Snyder, Michael, Velez, Daniel Ortiz, Xu, Guorong, Yu, Michael Ku, Zhang, Wei   +17 more
core   +1 more source

Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci

Molecular Autism, 2012
Background Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common variants with autism susceptibility risk
Davis Lea K, Gamazon Eric R, Kistner-Griffin Emily, Badner Judith A, Liu Chunyu, Cook Edwin H, Sutcliffe James S, Cox Nancy J   +7 more
doaj   +1 more source

Interpreting Functional Impact of Genetic Variations by Network QTL for Genotype–Phenotype Association Study

Frontiers in Cell and Developmental Biology, 2022
An enormous challenge in the post-genome era is to annotate and resolve the consequences of genetic variation on diverse phenotypes. The genome-wide association study (GWAS) is a well-known method to identify potential genetic loci for complex traits ...
Kai Yuan, Tao Zeng, Tao Zeng, Tao Zeng, Luonan Chen, Luonan Chen, Luonan Chen, Luonan Chen   +7 more
doaj   +1 more source

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics' [PDF]

, 2005
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant ...
A Scherer, CE Muller-Sieburg, CS Potten, EE Schadt, ES Lander, F Lai, G de Haan, G De Haan, G De Haan, G Yvert, J Boultwood, J Klose, JL Peirce, LM Kamminga, M Ramalho-Santos, ML Wayne, NB Ivanova, NO Fortunel, P Hasty, RB Brem, RC Jansen, RC Jansen, SR Pearce, T Wiltshire, Y Ben-David   +24 more
core   +2 more sources

Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research [PDF]

, 2005
Alcoholism is a complex disease exhibiting a multifactorial mode of transmission. To simplify the genetic and phenotypic complexity of the alcoholic phenotype, alcohol-preferring (P) and -non-preferring (NP) rats were developed on the basis of alcohol ...
Carr, Lucinda G., Foroud, Tatiana, Liang, Tiebing, Lo, David, Spence, John P.   +4 more
core   +1 more source