Results 21 to 30 of about 132,242 (193)

A mega-analysis of expression quantitative trait loci in retinal tissue. [PDF]

PLoS Genetics, 2020
Significant association signals from genome-wide association studies (GWAS) point to genomic regions of interest. However, for most loci the causative genetic variant remains undefined.
Tobias Strunz, Christina Kiel, Felix Grassmann, Rinki Ratnapriya, Madeline Kwicklis, Marcus Karlstetter, Sascha Fauser, Nicole Arend, Anand Swaroop, Thomas Langmann, Armin Wolf, Bernhard H F Weber   +11 more
doaj   +2 more sources

Identifying cancer tissue-of-origin by a novel machine learning method based on expression quantitative trait loci. [PDF]

Front Oncol, 2022
Miao Y, Zhang X, Chen S, Zhou W, Xu D, Shi X, Li J, Tu J, Yuan X, Lv K, Tian G.   +10 more
europepmc   +3 more sources

Meta-Analyses of Splicing and Expression Quantitative Trait Loci Identified Susceptibility Genes of Glioma [PDF]

Frontiers in Genetics, 2021
BackgroundThe functions of most glioma risk alleles are unknown. Very few studies had evaluated expression quantitative trait loci (eQTL), and insights of susceptibility genes were limited due to scarcity of available brain tissues.
C. Pawan K. Patro, Darryl Nousome, The Glioma International Case Control Study (GICC), Rose K. Lai, Elizabeth B. Claus, Dora Il’yasova, Joellen Schildkraut, Jill S. Barnholtz-Sloan, Sara H. Olson, Jonine L. Bernstein, Christoffer Johansen, Robert B. Jenkins, Beatrice S. Melin, Margaret R. Wrensch, Richard S. Houlston, Melissa L. Bondy   +15 more
doaj   +2 more sources

Characterizing the Relationship between Expression Quantitative Trait Loci (eQTLs), DNA Methylation Quantitative Trait Loci (mQTLs), and Breast Cancer Risk Variants. [PDF]

Cancers (Basel)
Ho PJ, Khng A, Tan BK, Khor CC, Tan EY, Lim GH, Yuan JM, Tan SM, Chang X, Tan VKM, Sim X, Dorajoo R, Koh WP, Hartman M, Li J.   +14 more
europepmc   +3 more sources

Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes [PDF]

Nature Communications
Transcriptome-wide association study (TWAS) is a popular approach to dissect the functional consequence of disease associated non-coding variants. Most existing TWAS use bulk tissues and may not have the resolution to reveal cell-type specific target ...
Lida Wang, Chachrit Khunsriraksakul, Havell Markus, Dieyi Chen, Fan Zhang, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang. J. Liu, Bibo Jiang   +9 more
doaj   +2 more sources

Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas

Cells, 2023
In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Géraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sébastien Jacques, Colin E. Murdoch, Francisco Miralles, Céline Méhats, Daniel Vaiman   +12 more
doaj   +1 more source

Expression quantitative trait loci associated with Nellore meat pH. [PDF]

, 2023
Genomic studies make it possible to identify polymorphisms associated with quantitative characteristics of economic interest, such as meat pH, a factor that influences meat ...
BEATRIZ, D. L., COUTINHO, L. L., GARCIA, I. S., REGITANO, L. C. de A., SILVA, T. R. da, SILVA-VIGNATO, B.   +5 more
core  

Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice

Journal of Lipid Research, 2011
To identify genetic loci influencing lipid levels, we performed quantitative trait loci (QTL) analysis between inbred mouse strains MRL/MpJ and SM/J, measuring triglyceride levels at 8 weeks of age in F2 mice fed a chow diet.
Magalie S. Leduc, Rachael S. Hageman, Ricardo A. Verdugo, Shirng-Wern Tsaih, Kenneth Walsh, Gary A. Churchill, Beverly Paigen   +6 more
doaj   +1 more source

Expression quantitative trait loci (eQTL) mapping in Puerto Rican children. [PDF]

PLoS ONE, 2015
Expression quantitative trait loci (eQTL) have been identified using tissue or cell samples from diverse human populations, thus enhancing our understanding of regulation of gene expression.
Wei Chen, John M Brehm, Jerome Lin, Ting Wang, Erick Forno, Edna Acosta-Pérez, Nadia Boutaoui, Glorisa Canino, Juan C Celedón   +8 more
doaj   +1 more source

Expression quantitative trait loci analysis in plants [PDF]

, 2010
An expression Quantitative Trait Locus or eQTL is a chromosomal region that accounts for a proportion of the variation in abundance of a mRNA transcript observed between individuals in a genetic mapping population.
Chen, Xinwei, Druka, Arnis, Jiang, Ning, Kearsey, Mike, Luo, Zewei, Potokina, Elena, Waugh, Robbie   +6 more
core   +2 more sources