Heritability and tissue specificity of expression quantitative trait loci.
PLoS Genetics, 2006 Variation in gene expression is heritable and has been mapped to the genome in humans and model organisms as expression quantitative trait loci (eQTLs). We applied integrated genome-wide expression profiling and linkage analysis to the regulation of gene
Enrico Petretto +11 more
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Variation in the flowering time orthologs BrFLC and BrSOC1 in a natural population of Brassica rapa. [PDF]
, 2015 Understanding the genetic basis of natural phenotypic variation is of great importance, particularly since selection can act on this variation to cause evolution.
Franks, Steven J +7 more
core +2 more sources
Genome-wide expression quantitative trait loci (eQTL) analysis in maize
BMC Genomics, 2011 Background Expression QTL analyses have shed light on transcriptional regulation in numerous species of plants, animals, and yeasts. These microarray-based analyses identify regulators of gene expression as either cis-acting factors that regulate ...
Beatty Mary +4 more
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Rapid and robust association mapping of expression quantitative trait loci [PDF]
, 2007 We applied a simple and efficient two-step method to analyze a family-based association study of gene expression quantitative trait loci (eQTL) in a mixed model framework. This two-step method produces very similar results to the full mixed model method,
Aulchenko, Yurii S +4 more
core +2 more sources
Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study
BMC Genomics, 2008 Background Many studies have shown that the abundance level of gene expression is heritable. Analogous to the traditional genetic study, most researchers treat the expression of one gene as a quantitative trait and map it to expression quantitative trait
Sun Wei, Yuan Shinsheng, Li Ker-Chau
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Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 [PDF]
, 2017 Background: We have previously confirmed the importance of rat chromosome 3 (RNO3) genetic loci on blood pressure elevation, pulse pressure (PP) variability and renal pathology during salt challenge in the stroke-prone spontaneously hypertensive (SHRSP ...
Beattie, Wendy +8 more
core +6 more sources
Common Expression Quantitative Trait Loci Shared by Histone Genes
International Journal of Genomics, 2017 A genome-wide association study (GWAS) was conducted to examine expression quantitative trait loci (eQTLs) for histone genes. We examined common eQTLs for multiple histone genes in 373 European lymphoblastoid cell lines (LCLs).
Hanseol Kim, Yujin Suh, Chaeyoung Lee
doaj +1 more source
Modeling expression quantitative trait loci in data combining ethnic populations
BMC Bioinformatics, 2010 Background Combining data from different ethnic populations in a study can increase efficacy of methods designed to identify expression quantitative trait loci (eQTL) compared to analyzing each population independently.
Hsieh Ai-Ru +3 more
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Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
A geometric interpretation of the permutation $p$-value and its application in eQTL studies [PDF]
, 2010 Permutation $p$-values have been widely used to assess the significance of linkage or association in genetic studies. However, the application in large-scale studies is hindered by a heavy computational burden.
Sun, Wei, Wright, Fred A.
core +3 more sources