Results 101 to 110 of about 3,834 (197)

Rethinking Proteinuria: Resolution of Donor Derived EXT2‐Associated Membranous Nephropathy Following Renal Transplantation

Case Reports in Transplantation, Volume 2026, Issue 1, 2026.
Exostosin‐2 (EXT2)‐associated membranous nephropathy (MN) represents a subgroup of immune complex‐mediated renal diseases, where transplantation may facilitate clearance of immune deposits. We present a successful kidney transplantation from a 19‐year‐old deceased donor with previously undiagnosed EXT2‐associated MN into a 75‐year‐old male recipient ...
Mike Fruscione, Devarsh Desai, Satoru Kudose, Yasir Qazi, Samuel Sultan, Kenneth Lieberman, Michael J. Goldstein, Richa Sharma   +7 more
wiley   +1 more source

Hsa_Circ_0008035 drives immune evasion of gastric cancer via promoting EXT1-mediated nuclear translocation of PKM2

Translational Oncology
Circular RNAs (circRNAs) have been reported to be associated with the malignant phenotypes of cancer. However, the role and underlying mechanism of hsa_Circ_0008035 in colorectal cancer (CRC) remains unclear. In this study, we elucidated the pivotal role
Rongqi Jiang, Ping Li, Enqing Meng, Xu Cheng, Xinyi Wu, Hao Wu   +5 more
doaj   +1 more source

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis [PDF]

, 2000
The D-glucuronyltransferase and N-acetyl-D-glucosaminyltransferase reactions in heparan sulfate biosynthesis have been associated with two genes, EXT1 and EXT2, which are also implicated in the inherited bone disorder, multiple exostoses.
Kerstin Lidholt, Tone, Y, Sugahara, K, Thomas Lind, Hiroshi Kitagawa, Senay, Clair,, Lindahl, Ulf,, Kazuyuki Sugahara, Muguruma, K, Claire Senay, Kitagawa, H, Yuko Tone, Lind, Thomas,, Marion Kusche‐Gullberg, Ulf Lindahl, Kumi Muguruma, Lidholt, Kerstin,, Kusche-Gullberg, Marion,   +17 more
core   +1 more source

Cases report: Mosaic structural variants of the EXT1 gene in previously genetically unconfirmed multiple osteochondromas

Frontiers in Genetics
Multiple osteochondromas (MO) is a rare autosomal dominant skeletal disorder characterized by the development of multiple benign tumors known as osteochondromas. The condition is predominantly caused by loss-of-function variants in the EXT1 or EXT2 genes,
Artem Borovikov, Andrey Marakhonov, Aysylu Murtazina, Kseniya Davydenko, Alexandra Filatova, Nailya Galeeva, Varvara Kadnikova, Natalya Ogorodova, Daria Gorodilova, Ilya Kanivets, Ilya Kanivets, Denis Pyankov, Konstantin Zherdev, Konstantin Zherdev, Aleksandr Petel’guzov, Pavel Zubkov, Alexander Polyakov, Olga Shchagina, Mikhail Skoblov   +18 more
doaj   +1 more source

Hereditary Multiple Exostoses: Clinical, Molecular and Radiologic Survey in 9 Families

Prague Medical Report, 2017
Hereditary multiple exostoses (HME) represents a heterogeneous group of diseases often associated with progressive skeletal deformities. Most frequently, mutations in EXT1 and EXT2 genes with autosomal dominant inheritance are responsible for HME. In our
Karel Medek, Jiří Zeman, Tomáš Honzík, Hana Hansíková, Štěpánka Švecová, Kamila Beránková, Vendula Kučerová Vidrová, Miloslav Kuklík, Jiří Chomiak, Markéta Tesařová   +9 more
doaj   +1 more source

Tumor promotion or suppression: Revisiting the role of EXT1 and Heparan sulfate.

Histology and histopathology
Heparan sulfate (HS), a linear sulfated polysaccharide attached to proteoglycans, modulates the availability and activity of growth factors and cytokines to regulate cell signaling, adhesion, and migration. Exostosin-1 (EXT1), a key glycosyltransferase for HS chain elongation, is increasingly implicated in cancer development and progression.
Hiroyuki Tomita, Akira Hara, Ayumi Niwa
openaire   +3 more sources

A note on vanishing of the functor ext1 for Köthe spaces [PDF]

, 1991
In this note we study the relationship between the vanishing of Ext1(λ(A), λ(A)) and the existence of a regular basis in the Köthe space λ(A). We construct an example of a nuclear Köthe space λ(A) with no regular basis and such that Ext1(λ(A), λ(A))=0 ...
Kocatepe, M.
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Mutations in the EXT1 and EXT2 genes in Spanish patients with multiple osteochondromas

Multiple osteochondromas is an autosomal dominant skeletal disorder characterized by the formation of multiple cartilage-capped tumours. Two causal genes have been identified, EXT1 and EXT2, which account for 65% and 30% of cases, respectively.
Urreizti Frexedas, Roser, Torner Rubies, Ferran, Asteggiano, Carla, Balcells Comas, Susana, Sangorrin, A., Artuch Iriberri, Rafael, Sarrión Pérez-Caballero, Patricia, Martorell, L., Lapunzina, P., Delgado, A., Antón López, Jordi, Grinberg Vaisman, Daniel Raúl, Armstrong i Morón, Judith, Vilaseca, M.A., Nevado, J.   +14 more
core   +3 more sources

Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids.

PLoS ONE, 2012
BackgroundStromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis. Heparan sulfate proteoglycans, present both
Cecilia Österholm, Ning Lu, Åsa Lidén, Tine V Karlsen, Donald Gullberg, Rolf K Reed, Marion Kusche-Gullberg   +6 more
doaj   +1 more source