Results 51 to 60 of about 492,732 (252)
Extended‐release buprenorphine in pregnancy
The American Journal on AddictionsAbstractBackground and ObjectivesThe relative safety and efficacy of monthly extended‐release buprenorphine (XR‐BUP) has not been fully evaluated in pregnant persons.MethodsCase report of two pregnant individuals receiving XR‐BUP while pregnant.ResultsBoth patients had positive experiences and healthy infants.Discussion and ConclusionsSparse data ...
Alexander Hubbell +3 more
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
PharmaceuticsThe mathematical models available in DDSolver were applied to experimental dissolution data obtained by analysing carvedilol release from hypromellose (HPMC)-based matrix tablets.
Tadej Ojsteršek +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
PharmaceuticsBackground/Objectives: This study investigated how selected functionality-related characteristics (FRCs) of hypromellose (HPMC)—namely viscosity, hydroxypropoxy substitution, particle size, and the ratio of water-soluble (FlowLac® 100) to water-insoluble
Tadej Ojsteršek +2 more
doaj +1 more source
Pramipexole Extended Release: A Novel Treatment Option in Parkinson's Disease
Parkinson's Disease, 2010 Pramipexole, the most commonly prescribed dopamine agonist worldwide, meanwhile serves as a reference substance for evaluation of new drugs. Based on numerous clinical data and vast experiences, efficacy and safety profiles of this non-ergoline dopamine ...
Wolfram Eisenreich +3 more
doaj +1 more source
Treatment of ADHD: Guanfacine Extended Release in ADHD
Pediatric Neurology Briefs, 2014 Investigators at Massachusetts General Hospital, Boston, MA, performed a multicenter, 9-week, double-blind, placebo-controlled, dose-optimization study of guanfacine extended release (GXR,
J Gordon Millichap, John J Millichap
doaj +1 more source
Advances of Nano-Structured Extended-Release Local Anesthetics
Nanoscale Research Letters, 2020 Extended-release local anesthetics (LAs) have drawn increasing attention with their promising role in improving analgesia and reducing adverse events of LAs.
Yumiao He +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source