Results 51 to 60 of about 5,738 (242)

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

High-Security Image Encryption Using Baker Map Confusion and Extended PWAM Chaotic Diffusion

Computers
The heavy use of digital images across network systems has become a major concern regarding data confidentiality and unauthorized access. Conventional image encryption techniques hardly achieve high security levels efficiently, especially in real-time ...
Ayman H. Abd El-Aziem, Marwa Hussien Mohamed, Ahmed Abdelhafeez   +2 more
doaj   +1 more source

Encoding Cumulation to Learn Perturbative Nonlinear Oscillatory Dynamics

Advanced Science, EarlyView.
Weak nonlinearities critically shape the long term behavior of oscillatory systems but are difficult to identify from data. A data‐driven framework is introduced to infer governing equations of weakly nonlinear oscillators from sparse and noisy observations.
Teng Ma, Ting‐Ting Gao, Wei Cui, Attilio Frangi, Gang Yan, Lin Zhao   +5 more
wiley   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Dynamical analysis and soliton solutions of the space–time fractional Kaup–Boussinesq system

Partial Differential Equations in Applied Mathematics
This research investigates the dynamics of the fractional Kaup–Boussinesq system. Dynamical tools, such as phase portraits, bifurcation diagrams, Poincaré maps, Lyapunov exponents, and sensitivity diagrams, are employed to illustrate the system’s ...
Amjad Hussain, Muhammad Hammad, Ariana Abdul Rahimzai, Wei Sin Koh, Ilyas Khan   +4 more
doaj   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

Advanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang, Mengyi Xu, Yan Zhang, Zhiwen Li, Danqing Song, Jing Pang, Ke Li, Yanxiang Wang   +7 more
wiley   +1 more source

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

Advanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel   +9 more
wiley   +1 more source

Vapor‐Assisted Catalysis Enables Precise Construction of MOF‐Derived Hierarchical Carbon Nanoarrays for High‐Performance Supercapacitors

Advanced Science, EarlyView.
A remote‐control strategy for catalyst design is unveiled for advanced carbon materials. During pyrolysis, zinc vapor from a physically separate source guides cobalt catalysts to construct a hierarchical carbon nanoarray. This approach prevents structural collapse while directing the dense growth of carbon nanotubes, yielding a material with ...
Xiaoyang Deng, Zihao Wan, Huan Xin, Xiaoguang Wang, Wenjuan Wang, Feixiong Chen, Liying Ma, Naiqin Zhao   +7 more
wiley   +1 more source

Security-enhanced three-factor remote user authentication scheme based on Chebyshev chaotic maps

International Journal of Distributed Sensor Networks, 2019
With the wide deployment of new computing paradigms, such as cloud computing and edge computing, the people can access services provided by remote servers more conveniently via the Internet. To preserve the security of those messages transmitted over the
Yan Zhao, Shiming Li, Liehui Jiang, Tieming Liu   +3 more
doaj   +1 more source