Results 51 to 60 of about 6,808,722 (274)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Identification of Dielectric Response Parameters of Pumped Storage Generator-Motor Stator Winding Insulation Based on Sparsity-Enhanced Dynamic Decomposition of Depolarization Current

Energies
Accurate diagnosis of the insulation condition of stator windings in pumped storage generator-motor units is crucial for ensuring the safe and stable operation of power systems.
Guangya Zhu, Shiyu Ma, Shuai Yang, Yue Zhang, Bingyan Wang, Kai Zhou   +5 more
doaj   +1 more source

Evaluation of the Region of Attractions of Higher Dimensional Hyperbolic Systems using the Extended Dynamic Mode Decomposition

CoRR, 2022
This paper proposes an original methodology to compute the regions of attraction in hyperbolic and polynomial nonlinear dynamical systems using the eigenfunctions of the discrete-time approximation of the Koopman operator given by the extended dynamic mode decomposition algorithm.
Camilo Garcia-Tenorio, Duvan Tellez-Castro, Eduardo Mojica-Nava, Alain Vande Wouwer   +3 more
openaire   +3 more sources

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

EEG-Based Detection of Induced Relaxation

IEEE Access
Relaxation, which refers to the absence of tension and stress, is important for health because extended periods of tension may lead to illness. This study detected induced relaxation through electroencephalography (EEG) for the real-time monitoring of ...
Bunyarat Umsura, Wanus Srimaharaj, Phakkharawat Sittiprapaporn, Nina Bencheva, Ratchuporn Suksathan, Roungsan Chaisricharoen   +5 more
doaj   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Advancing Logistics Management: E3L-Net for Predictive Demand Analytics

IEEE Access
The essence of smart logistics lies in leveraging information resources and intellectual assets to efficiently and precisely match the multidimensional demands and supplies within the logistics system.
Yao Lu
doaj   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Dynamic mode decomposition method

, 2022
Darbs ir veltīts dinamisko modu dekompozīcijas metodei, tās pamatidejai, teorijai, algoritmam, priekšrocībām, trūkumiem, aktualitātei un dinamisko sistēmu pētīšanai.
Vedennikova, Ekaterina
core