Results 61 to 70 of about 514,808 (265)
Design and evaluation of nicorandil extended-release tablet
Asian Journal of Pharmaceutical Sciences, 2015 The aim of this study was to design and evaluate extended-release formulations of a model drug, nicorandil, in order to achieve the desired steady-state plasma concentration of drug in vivo.
Ju-Young Kim +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Profile of extended-release oxycodone/acetaminophen for acute pain
, 2015 Mary Hanna Bekhit1–51David Geffen School of Medicine, 2Ronald Reagan UCLA Medical Center, 3UCLA Ambulatory Surgery Center, 4UCLA Wasserman Eye Institute, 5UCLA Martin Luther King Community Hospital, University of California Los Angeles, Los Angeles,
Bekhit MH
core
Exenatide extended-release: a once weekly treatment for patients with type 2 diabetes
, 2014 Katherine V Mann,1 Philip Raskin2 1PharmD Consulting, LLC, Royal Oak, MD, USA; 2Department of Internal Medicine, Division of Endocrinology, the University of Texas Southwestern Medical Center, Dallas, TX, USA Background: This article reviews the ...
Mann KV +3 more
core +1 more source
git-sunao/fft-extended-source: v1.0.0
, 2022 This is the first release of fft-extended ...
git-sunao
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Update on prescription extended-release opioids and appropriate patient selection
, 2013 Michael J Brennan The Pain Center of Fairfield, Fairfield, CT, USA Abstract: Chronic pain is largely underdiagnosed, often undertreated, and expected to increase as the American population ages. Many patients with chronic pain require long-term treatment
Brennan MJ
core
Materials & Design, 2020 Efficacy and safety are fundamental qualities to uphold and improve when developing an extended-release carrier system for local anesthetics (LAs).
Yumiao He +7 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source