Results 1 to 10 of about 492,633 (153)

Bioequivalence of oxymorphone extended release and crush-resistant oxymorphone extended release

Drug Design, Development and Therapy, 2011
Irma H Benedek, Janet Jobes, Qinfang Xiang, William D Fiske Endo Pharmaceuticals Inc, Chadds Ford, PA, USA Background: A formulation of crush-resistant extended-release opioids may deter abuse. The purpose of this study was to evaluate the bioequivalence
Fiske WD, Xiang Q, Jobes J, Benedek IH
doaj   +6 more sources

Trends in Extended-Release and Non-Extended-Release Buprenorphine Dispensing.

JAMA Netw Open
This cross-sectional study of buprenorphine prescription data in a US state examines relative changes in prescriptions of extended-release and non–extended-release versions, along with prescription characteristics.
Stopka TJ, Dalvi N, Young LD, Shrestha S, Valerio DD, Walley AY.   +5 more
europepmc   +3 more sources

Comparative bioequivalence of 1 mg and 4 mg tacrolimus extended-release tablets: randomized, open label, fully replicate, crossover trials in healthy adult subjects [PDF]

Frontiers in Nephrology
IntroductionThese studies were planned to establish bioequivalence between two doses (1-mg and 4-mg) of test product (tacrolimus extended-release tablets manufactured by Intas Pharmaceuticals Ltd., India) with reference product (Envarsus XR® manufactured
Jay Kumar Sharma, Deepak Bunger, Hemant Zaveri, Alok Chaturvedi   +3 more
doaj   +2 more sources

Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets

Asian Journal of Pharmaceutical Sciences, 2019
The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques.
Hui Xu, Li Liu, Xuehui Li, Junyuan Ma, Rui Liu, Shaoning Wang   +5 more
doaj   +3 more sources

Water insoluble polymers as efficient binder in fluid bed granulation of metoprolol for preparation hydrophilic matrix extendedrelease tablets [PDF]

Romanian Journal of Pharmaceutical Practice, 2020
Objectives. The objective of this study was to investigate the possibility of developing metoprolol extended-release tablets by using hydroxypropyl methylcellulose (HPMC) in order to obtain the hydrophilic matrix and Eudragit NE 40D, Kollicoat SR 30D and
Dana Hales, Cristian Alecu, Ioan Tomuţă   +2 more
doaj   +1 more source

Methylphenidate Multiphasic Release Tablet: Bioequivalence Assessment between Two Formulations Administered under Fasting and Fed Conditions

Pharmaceutics, 2023
Methylphenidate hydrochloride is used to treat children, adolescents, and adults with attention deficit/hyperactivity disorder (ADHD). Multiphasic release formulation has been used to control drug levels, mainly during children’s school period.
Marcelo Gomes Davanço, Jessica Meulman, Thalita Martins da Silva, Fernando Costa, Karini Bruno Bellorio, Iram Moreira Mundim, Ana Carolina Costa Sampaio, Leonardo de Souza Teixeira, Celso Francisco Pimentel Vespasiano   +8 more
doaj   +1 more source

Retrospective Analysis of Heartworm (Dirofilia immitis) Prevention Medication Compliance and Economic Value in Dogs in Veterinary Practices in Australia

Frontiers in Veterinary Science, 2021
Background: Canine heartworm (HW) is endemic in Australia. Prevention usually involves monthly topical or oral preventives, or annual injections of extended-release moxidectin (ProHeart SR-12*1), hereafter referred to as injectable moxidectin (IM).
Kennedy Mwacalimba, Andrea Wright, Konstantinos Giannakakis, Richard L'Estrange, Tinh-Son Nguyen   +4 more
doaj   +1 more source

Micro-Injection Moulding of PEO/PCL Blend–Based Matrices for Extended Oral Delivery of Fenbendazole

Pharmaceutics, 2023
Fenbendazole (FBZ) is a broad-spectrum anthelmintic administered orally to ruminants; nevertheless, its poor water solubility has been the main limitation to reaching satisfactory and sustained levels at the site of the target parasites.
Gilberto S. N. Bezerra, Gabriel G. De Lima, Declan M. Colbert, Elaine Halligan, Joseph Geever, Luke Geever   +5 more
doaj   +1 more source

Changing the Drug Delivery System: Does It Add to Non-Compliance Ramifications Control? A Simulation Study on the Pharmacokinetics and Pharmacodynamics of Atypical Antipsychotic Drug

Pharmaceutics, 2020
This study investigates the pharmacokinetic (PK) and pharmacodynamic (PD) consequences of shifting from Quetiapine fumarate immediate-release (IR) to extended-release (XR) formulation in non-adherent schizophrenia patients.
Mohammed H. Elkomy
doaj   +1 more source

Preparation, Properties and Sustained-release Properties of Naringin-loaded Cyclodextrin-polysaccharide-based Gel Spheres

Shipin gongye ke-ji, 2023
In order to make naringin have better water solubility and sustained release performance, hydroxypropyl-β-cyclodextrin was used to have strong adhectogenic ability for naringenin.
Wenjuan ZHANG, Meiyu ZHENG, Shengmin LU, Lu WANG, Yangguang WANG   +4 more
doaj   +1 more source