Results 11 to 20 of about 492,732 (252)
Zein as an Effective Carrier for Hesperidin Delivery Systems with Improved Prebiotic Potential
Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailability—
Szymon Sip +4 more
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Naltrexone Extended-Release Plus Bupropion Extended-Release for Treatment of Obesity [PDF]
In September 2014, a proprietary formulation of naltrexone-extended release plus bupropion -extended release (NB) (brand name, Contrave) was approved by the US Food and Drug Administration (FDA),1 becoming the fourth medication approved for long-term weight management in patients with obesity.2 Liraglutide (brand name, Saxenda), a glucagon-like peptide
Susan Z, Yanovski, Jack A, Yanovski
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Fast is a tool designed for the analysis of counter systems, i.e. automata extended with unbounded integer variables. Despite the reachability set is not recursive in general, Fast implements several innovative techniques such as acceleration and circuit selection to solve this problem in practice.
Bardin, Sébastien +2 more
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Polymers for extended-release administration [PDF]
Developing strategies to deliver the required dose of therapeutics into target tissues and cell populations within the body is a principal aim of controlled release and drug delivery. Specifically, there is an interest in developing formulations that can achieve drug concentrations within the therapeutic window, for extended periods of time, with ...
Marion S. Paolini +4 more
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Topical Inserts: A Versatile Delivery Form for HIV Prevention
The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP) dosage forms. They
M. Melissa Peet +7 more
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Solid dosage forms based on hypromellose (HPMC) with prolonged/extended drug release are very important from the research and industrial viewpoint. In the present research, the influence of selected excipients on carvedilol release performance from HPMC ...
Tadej Ojsteršek +2 more
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ZL-004, a promising small molecule that increases white blood cell counts, was developed for extended-release nanosuspensions to improve low solubility and compliance of patients. In vivo pharmacokinetic studies of nanosuspensions with different particle
Chengyue Guo +6 more
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α2-Adrenoceptor agonists are used adjunctively to psychostimulants in treating attention-deficit/hyperactivity disorder (ADHD) when psychostimulants alone do not sufficiently reduce symptoms. However, data on the pharmacokinetic profiles and safety of combination treatments in ADHD are needed.The primary objective of this study was to evaluate the ...
Roesch, Benno +7 more
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Treatment-Continuity of ADHD Compared Using Immediate-Release and Extended-Release MPH
The continuity of methylphenidate (MPH) therapy for ADHD in young Medicaid beneficiaries (ages 6 to 17 years) treated with immediate-release (IR) or extended-release (ER) MPH formulations was compared in an analysis of statewide California Medicaid ...
J Gordon Millichap
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Icariin (ICA) is a major flavonoid that contains the active compound Epimedii Folium. However, ICA’s pharmacokinetic characteristics remain unsatisfactory due to its low bioavailability, and hence limited drugability.
Lu-Ying Han +4 more
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