Results 61 to 70 of about 19,987 (262)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Planetary Vulnerability and Hope of Habitability: A Select Study of Ecoprecarity in Contemporary Video-Game Narratives

ILN Journal: Indian Literary Narratives
 Of late, video games have turned into a new form of literature within the evolving society. What was once shunned under the pretext of childish initiations has now gained popularity and respect, encompassing simultaneously a sports culture along with ...
Prabal Dweep Debbarma, Dr. Aditya Ghosh
doaj   +1 more source

An investigation into the Impacts of CALL/DGBL Endeavors on Upgrading EFL Learners’ Communicative Competence

Zanco Journal of Humanity Sciences, 2019
The current study is an experimental digital game-based (DGBL) endeavor which tackles potential educational issues beyond the frequent use of games, language learning potentials in particular. It is characterized by a quantitative research design.
Rozhgar Jalal Khidhir, Hussein Ali Wali
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Responsibility in Extensive Form Games

Proceedings of the AAAI Conference on Artificial Intelligence
Two different forms of responsibility, counterfactual and seeing-to-it, have been extensively discussed in philosophy and AI in the context of a single agent or multiple agents acting simultaneously. Although the generalisation of counterfactual responsibility to a setting where multiple agents act in some order is relatively straightforward, the same ...
openaire   +2 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

A Review on Blockchain-based Gaming: Existing Insights, Deficits, and Emerging Avenues [PDF]

Journal of Applied Research in Electrical Engineering
Gaming is the notion of playing electronic games that involves users in the form of avatars or characters engaging with an interactive digital experience to achieve a specific gaming objective.
Patikiri Arachchige Don Shehan Nilmantha Wijesekara
doaj   +1 more source

Coarse Correlation in Extensive-Form Games

Proceedings of the AAAI Conference on Artificial Intelligence, 2020
Coarse correlation models strategic interactions of rational agents complemented by a correlation device which is a mediator that can recommend behavior but not enforce it. Despite being a classical concept in the theory of normal-form games since 1978, not much is known about the merits of coarse correlation in extensive-form settings. In this paper,
Gabriele Farina, Tommaso Bianchi, Tuomas Sandholm   +2 more
openaire   +3 more sources

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source