Results 111 to 120 of about 3,057,829 (262)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Repurposing and Revival of the Drugs: A New Approach to Combat the Drug Resistant Tuberculosis

Frontiers in Microbiology, 2017
Emergence of drug resistant tuberculosis like multi drug resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and totally drug resistant tuberculosis (TDR-TB) has created a new challenge to fight against these bad bugs of ...
Divakar Sharma, Divakar Sharma, Yogesh K. Dhuriya, Nirmala Deo, Deepa Bisht   +4 more
doaj   +1 more source

Prevalence of Pre-Extensively Drug Resistant Tuberculosis, Extensively Drug Resistant Tuberculosis among the Multi Drug Resistant Tuberculosis Patients

BMC Journal of Medical Sciences
Abstract Background: Multidrug-resistant tuberculosis (MDRTB) is a growing global health concern that is a chronic danger to world health due to tuberculosis (TB). Objective: The aim of this study was to examine the frequency of both pre extensively drug-resistant tuberculosis (PXDRTB) and extensively drug-resistant tuberculosis (EXDRTB) in patients ...
Salman khan, Naseeb-Ur -Rehman, Mohammad Zubair, Nisar Khan   +3 more
openaire   +1 more source

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target [PDF]

, 2014
The human pathogen Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis (TB), a disease with high worldwide mortality rates. Current treatment programs are under significant threat from multi-drug and extensively-drug resistant ...
VijayaShankar Nataraj, Reynolds Robert C., Nicholas J Loman, Lloyd, AJ, Besra, Gurdyal S., Klaus Fütterer, Ballell, L, Reynolds, Robert C., Abrahams, Katherine A, Loman, Nicholas J., Hobrath Judith V., Gurcha Sudagar S., Alderwick, LJ, Abrahams, Katherine A., Gurcha, SS, Cox, Jonathan A G, Abrahams Katherine A., Hobrath, JV, Loman, Nicholas J, Carlos Alemparte, Lluis Ballell, Bhatt, Apoorva; id_orcid, Cox Jonathan A. G., Loman, NJ, Besra, GS, Reynolds, Robert C, Alemparte Carlos, Alderwick, Luke J, Gurcha, Sudagar S, Besra, Gurdyal S; id_orcid, Abrahams, KA, Besra Gurdyal S., Hobrath, Judith V, Barros, D, Robert C Reynolds, Loman Nicholas J., Bhatt, A, Ballell, Lluis, Nataraj, VijayaShankar, Lloyd, Adrian J., Apoorva Bhatt, Bhatt Apoorva, Nataraj, V, Alemparte, Carlos, Lloyd, Adrian J, Fütterer, K, Hobrath, Judith V., Veeraraghavan Usha, Cox, Jonathan A. G., Cox, JA, Barros David, Veeraraghavan, Usha, Bhatt, Apoorva, Adrian J Lloyd, Jonathan A G Cox, Usha, V, Gurdyal S Besra, David Barros, Lloyd Adrian J., Reynolds, RC, Alderwick, Luke J., Ballell Lluis, Usha Veeraraghavan, Fütterer Klaus, Barros, David, Nataraj, Vijaya-Shankar, Luke J Alderwick, Gurcha, Sudagar S., Alderwick Luke J., Judith V Hobrath, Sudagar S Gurcha, Usha, Veeraraghavan, Nataraj VijayaShankar, Alemparte, C, Fütterer, Klaus, Katherine A Abrahams   +75 more
core   +1 more source

Multimodal artificial intelligence in medical biotechnology: Integrating genomics, imaging, and clinical data for precision therapeutics

Precision Medical Sciences, EarlyView.
Overview of multimodal artificial intelligence (AI) for precision therapeutics. Diverse biomedical data modalities, including multi‐omics, medical imaging, digital pathology, electronic health records, wearable‐device data, and molecular information, are integrated through multimodal AI frameworks incorporating fusion strategies, foundation models ...
Gedion Mengistu Dejen
wiley   +1 more source

Drug-Resistant Tuberculosis, KwaZulu-Natal, South Africa, 2001–2007

Emerging Infectious Diseases, 2011
In Africa, incidence and prevalence of drug-resistant tuberculosis have been assumed to be low. However, investigation after a 2005 outbreak of extensively drug-resistant tuberculosis in KwaZulu-Natal Province, South Africa, found that the incidence rate
Kristina Wallengren, Fabio Scano, Paul Nunn, Bruce Margot, Sandile S.S. Buthelezi, Brian Williams, Alexander Pym, Elisabeth Y. Samuel, Fuad Mirzayev, Wilfred Nkhoma, Lindiwe Mvusi, Yogan Pillay   +11 more
doaj   +1 more source

Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment [PDF]

, 2009
The rapid detection of Mycobacterium tuberculosis isolates resistant to second-line drugs is crucial for the institution of appropriate treatment regimens as early as possible.
Braker, K, Zarkua, N, Niemann, S, Feuerriegel, S, Cox, H S, Rüsch-Gerdes, S, Karimovich, H A   +6 more
core   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

XDR TB in South Africa - What lies ahead?

South African Family Practice, 2007
The emergence of XDR TB coupled with the high prevalence of HIV/AIDS has intensified the need to identify new treatment strategies and accelerate research into antibiotics against XDR TB before the world is faced with a global public health crisis.
V. Thaver, Gboyega A. Ogunbanjo
doaj   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source