Results 101 to 110 of about 3,057,829 (262)

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Drug-Resistant Tuberculosis and HIV Infection: Current Perspectives

HIV/AIDS: Research and Palliative Care, 2020
Abhijeet Singh, 1 Rajendra Prasad, 1, 2 Viswesvaran Balasubramanian, 1 Nikhil Gupta 3 1Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, New Delhi, Delhi 110007, India; 2Department of Pulmonary Medicine, King ...
Singh A, Prasad R, Balasubramanian V, Gupta N   +3 more
doaj  

Multidrug-resistant tuberculosis in Lithuania – Still a long way ahead

Medicina, 2016
Despite the recent advances in the diagnosis of tuberculosis, treatment of the disease, for the most part, remains the same as it was half a century ago.
Greta Musteikienė, Skaidrius Miliauskas, Raimundas Sakalauskas, Astra Vitkauskienė, Marius Žemaitis   +4 more
doaj   +1 more source

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

Extensively Drug-Resistant Tuberculosis in Women, KwaZulu-Natal, South Africa

Emerging Infectious Diseases, 2011
To determine whether women in KwaZulu-Natal, South Africa, with drug-resistant tuberculosis (TB) were more likely than men to have extensively drug-resistant TB, we reviewed 4,514 adults admitted during 2003–2008 for drug-resistant TB.
Max R. O’Donnell, Jennifer Zelnick, Lise Werner, Iqbal Master, Marian Loveday, C. Robert Horsburgh, Nesri Padayatchi   +6 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Tuberculosis in London: The importance of homelessness, problem drug use and prison [PDF]

, 2007
Background: The control of tuberculosis (TB) is founded on early case detection and complete treatment of disease. In the UK, TB is concentrated in subgroups of the population in large urban centres.
Murad, S, Story, A, Verheyen, M, London Tuberculosis Nurses Network, Hayward, AC, Roberts, W   +5 more
core  

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Upper-Room Ultraviolet Light and Negative Air Ionization to Prevent Tuberculosis Transmission [PDF]

, 2009
Background Institutional tuberculosis (TB) transmission is an important public health problem highlighted by the HIV/AIDS pandemic and the emergence of multidrug- and extensively drug-resistant TB.
Ticona, E., Gilman, RH, Navincopa, Marcos, Gilman, R.H., Noakes, Catherine, Carlton A Evans, Patricia Sheen, Gilman Robert H, Gonzalez Armando, Ticona, Eduardo, Gonzalez, A, Mitchell, B., Ramirez, R., Moore, David AJ, Sheen, Patricia, Willi Quino, Mitchell Bailey, Noakes Catherine, Quino Willi, Robert H Gilman, Quino, W, Sheen Patricia, Rocio Ramirez, Armando Gonzalez, Navincopa, M., Sheen, P, Jon S Friedland, A Roderick Escombe, Gilman, Robert H, Martínez Carlos, Martinez, C, Ramirez, Rocio, Escombe, AR, Mitchell, Bailey, Evans, Carlton A, Gonzalez, A., Friedland, Jon S, Navincopa, M, Escombe A. Roderick, Noakes, CJ, Martínez, Carlos, Ramirez, R, Evans, CA, Evans, C.A., Quino, Willi, Bailey Mitchell, Carlos Martínez, Moore, D.A.J., Moore, DAJ, Catherine Noakes, Escombe, A.R., Friedland, J.S., Ticona, E, Moore David A. J, Mitchell, B, Navincopa Marcos, Noakes, C, David A J Moore, Ramirez Rocio, Quinow, W., Friedland Jon S, Noakes, C.J., Sheen, P., Friedland, JS, Martinez, C., Ticona Eduardo, Marcos Navincopa, Evans Carlton A, Gonzalez, Armando, Eduardo Ticona, Escombe, A Roderick   +70 more
core   +2 more sources

Adult‐onset CD8‐predominant hemispheric inflammatory epilepsy: Expanding the spectrum of post‐infectious and Rasmussen‐like encephalitis

Epileptic Disorders, EarlyView.
Ramya Raghupathi
wiley   +1 more source