Results 91 to 100 of about 3,405,067 (289)

Philanthropy under the Microscope: A Cost-Benefit Analysis of Small Nonprofits Conducting Financial Statement Audits [PDF]

, 2017
External audits are conducted by Certified Public Accountants (CPAs) and ensure the reliability of financial reporting and internal controls of a given organization. Publicly traded corporations are required by the Securities and Exchange Commission (SEC)
Samaniego, Sarah
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Do changing diagnostic criteria for gestational diabetes influence pregnancy outcome?

Acta Clinica Croatica, 2016
The incidence of pregnancy related diabetes has been steadily increasing during the past decade. The aim of this retrospective study was to evaluate the type and prevalence of gestational diabetes complications after implementing new diagnostic criteria ...
Ivka Djaković, Senka Sabolović Rudman, Vesna Gall, Andro Košec, Marina Markuš Sandrić, Vesna Košec   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Factors impacting on the external environment of the Arabic Maghrib Countries Union

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2006
The paper is focused on the Arabic Maghrib Countries. Relations of these countries in their different forms, political, economical, and sociological, have not suddenly appeared, but are founded on a long-term development.
Omran Mansur Essayah
doaj   +1 more source

Measurement Model of Evaluation Utilization: External Evaluation

Procedia - Social and Behavioral Sciences, 2012
AbstractIn Thailand, external evaluations are evaluated by The Office for National Education Standards and Quality Assessment (Public Organization) (ONESQA). The finding of external evaluation is useful for the improvement of education. Evaluation helps stakeholders to find out what works and what doesn’t.
Tochot, P., Junpeng, P., Makmee, P.
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ILO Minimum Estimate of Forced Labour in the World [PDF]

, 2005
Prepared for the ILO by Patrick Belser, Michaelle de Cock, and Farhad Mehran, this is a technical document that provides a detailed account of the methodology used in the ILO’s first minimum estimate of forced labour in the world, prepared in 2005.
Belser, Patrick, de Cock, Michaëlle, International Labour Organization, Mehran, Farhad   +3 more
core   +1 more source