Results 101 to 110 of about 1,020,393 (303)

Evaluation of the 20,000 days campaign [PDF]

open access: yes, 2014
The aim of Counties Manuaku District Health Board (CMDHB) 20,000 Days Campaign was to give back to the community 20,000 healthy and well days to avoid predicted growth in hospital bed days.
Jacqueline Cumming   +3 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Do changing diagnostic criteria for gestational diabetes influence pregnancy outcome?

open access: yesActa Clinica Croatica, 2016
The incidence of pregnancy related diabetes has been steadily increasing during the past decade. The aim of this retrospective study was to evaluate the type and prevalence of gestational diabetes complications after implementing new diagnostic criteria ...
Ivka Djaković   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Findings brief : external review of the Peace, Conflict and Development Program

open access: yes, 2010
French version available in IDRC Digital Library: Constatations en bref de l'examen externe du programme Paix, conflits et développementThis findings brief is based on the reports "External Review of IDRC's Peace, Conflict, and Development Program" by ...
IDRC. Evaluation Unit
core  

Conducting and Using Evaluability Assessments within CGIAR: CGIAR Evaluation Guidelines

open access: yes, 2022
In 2022, the CGIAR System Council and Board approved a CGIAR Evaluation Framework and a revised Evaluation Policy. Their development followed a consultative, inclusive, and iterative approach that included strategic and operational discussions with ...
CGIAR Independent Advisory and Evaluation Service
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

External school evaluation : teachers’ perspectives : two case studies from Northern Portugal [PDF]

open access: yes, 2015
The external evaluation of non-higher education schools in Portugal has been developed by the General Inspectorate of Education since 2006. A first cycle of evaluation was completed, covering all educational units in continental Portugal up to 2011.
Seabra, Filipa, Morgado, José Carlos
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Home - About - Disclaimer - Privacy