Results 111 to 120 of about 1,250,327 (305)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Differences in external loads of different pitch types in Chinese male college baseball players

Frontiers in Sports and Active Living
BackgroundIn baseball, monitoring player load solely through pitch count and innings overlooks the variability introduced by different pitch types. This study analyzed differences in external load, measured as Player Load, across various pitch types ...
Shenglei Qin, Dingmeng Ren, Zheng Li, Bo Zhang   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The effect of substitutions on match running performance and tactical-technical performance in the Qatar 2022 World Cup

European Journal of Human Movement
This study aimed to analyze the impact of substitutions on players match running and tactical technical performance during the FIFA World Cup Qatar 2022, considering the type of substitutions.
Borja Sanabria-Pino, David Lobo-Triviño, Jorge Polo-Tejada, Tomás García-Calvo, Jose Miguel Encinas-Borrego, José Carlos Ponce-Bordón   +5 more
doaj  

Training vs. Competition: Load and Intensity Differences Between Multi-Feeding and Simulated Match Play in High-Level Youth Badminton Players

Applied Sciences
Badminton is an intermittent sport with a diverse exercise profile that stresses both aerobic and anaerobic energy systems. The aim of this study was to compare the internal and external load profiles of multi-feeding (MF) drills and simulated match play
Francisco Alvarez-Dacal, Alejandro Rodríguez-Fernández, Alba Herrero-Molleda, Marina Gil-Calvo, Ernest Baiget, Jordi Seguí-Urbaneja, Jaime Fernández-Fernández   +6 more
doaj   +1 more source

INFLUENCE OF THE STIFFNESS AND FRICTIONAL CHARACTERISTICS ON THE SHANK TORQUE OF SCREWS IN BOLTED JOINTS [PDF]

, 2018
This work aims at determining the influence of tribological and stiffness characteristics of a bolted joint on the residual shank torque of the screw.
Cavalli, Omar, Croccolo, Dario, De Agostinis, Massimiliano, Fini, Stefano, Olmi, Giorgio, Robusto, Francesco, Vincenzi, Nicol\uf2   +6 more
core  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

The Influence of Weekly Training Load on Match Physical Demands in Spanish Professional Soccer Players: A Full In-Season Study

Sensors
This study aimed (i) to analyze the relationship between weekly accumulated training load (TL) and match physical demands in the same week and (ii) to describe the training/match ratios of different external load measures considering variations across ...
José C. Ponce-Bordón, Jorge Polo-Tejada, David Lobo-Triviño, Borja Sanabria-Pino, Javier Raya-González, Alberto Muñoz, Tomás García-Calvo   +6 more
doaj   +1 more source

An analysis of cross-coupling of a multicomponent jet engine test stand using finite element modeling techniques [PDF]

A two axis thrust measuring system was analyzed by using a finite a element computer program to determine the sensitivities of the thrust vectoring nozzle system to misalignment of the load cells and applied loads, and the stiffness of the structural ...
Schweikhard, W. G., Singnoi, W. N.
core   +1 more source