Results 71 to 80 of about 6,595,667 (193)

Opioid antagonist treatment in alcohol use disorder: extinction, reward memory, and the possible importance of timing

open access: yesFrontiers in Neuroscience
Opioid receptor antagonists, particularly naltrexone and nalmefene, are among the best-supported pharmacotherapies for alcohol use disorder (AUD), yet their clinical efficacy remains modest and highly heterogeneous. The mechanisms through which transient
Iiro P. Jääskeläinen
doaj   +1 more source

Fear extinction learning and anandamide: an fMRI study in healthy humans

open access: yesTranslational Psychiatry, 2021
Anxiety- and trauma-related disorders are severe illnesses with high prevalence. Current treatment options leave room for improvement and the endocannabinoid system (ECS) has become a key target in psychopharmacological research. Rodent models suggest an
Jennifer Spohrs   +7 more
doaj   +1 more source

Global remapping emerges as the mechanism for renewal of context-dependent behavior in a reinforcement learning model

open access: yesFrontiers in Computational Neuroscience
IntroductionThe hippocampal formation exhibits complex and context-dependent activity patterns and dynamics, e.g., place cell activity during spatial navigation in rodents or remapping of place fields when the animal switches between contexts ...
David Kappel, Sen Cheng
doaj   +1 more source

Fear extinction learning ability predicts neuropathic pain behaviors and amygdala activity in male rats

open access: yesMolecular Pain, 2018
Background The amygdala plays a key role in fear learning and extinction and has emerged as an important node of emotional-affective aspects of pain and pain modulation.
Guangchen Ji   +4 more
doaj   +1 more source

Implications of extinction in law: Preventing, declaring and learning from species extinctions

open access: yesCambridge Prisms: Extinction, 2023
Abstract Biodiversity laws around the world differ, but, at their core, these laws promote the fundamental objective of preventing environmental decline and species extinctions. A variety of legal mechanisms have been implemented in domestic laws around the world to achieve this objective, including protection for habitat ...
openaire   +3 more sources

Rethinking Extinction

open access: yes, 2015
Extinction serves as the leading theoretical framework and experimental model to describe how learned behaviors diminish through absence of anticipated reinforcement.
Niv, Yael   +7 more
core   +1 more source

Alterations in neuronal morphology in infralimbic cortex predict resistance to fear extinction following acute stress

open access: yesNeurobiology of Stress, 2016
Dysfunction in corticolimbic circuits that mediate the extinction of learned fear responses is thought to underlie the perseveration of fear in stress-related psychopathologies, including post-traumatic stress disorder.
Kelly M. Moench   +3 more
doaj   +1 more source

The Effect of Anticipatory Anxiety on Fear Extinction Learning [PDF]

open access: yes, 2021
Adaptive regulation of fear is dependent on successful fear extinction learning; therefore, investigating factors that both enhance and diminish fear extinction learning is a critical line of research.
Echeverria, Daniela C.
core  

The role of expectancy violation in extinction learning: a two-day virtual reality fear conditioning study

open access: yes, 2022
According to the inhibitory learning model, expectancy violation drives the formation of CS-no US associations during extinction learning. In this two-day virtual reality fear conditioning study, we plan to experimentally manipulate the amount of ...
Yannik Stegmann, Daniel Gromer
core   +1 more source

Involvement of dopamine D1/D5 and D2 receptors in context-dependent extinction learning and memory reinstatement

open access: yesFrontiers in Behavioral Neuroscience, 2016
Dopamine contributes to the regulation of higher order information processing and executive control. It is important for memory consolidation processes, and for the adaptation of learned responses based on experience.
Marion Agnes Emma Andre   +1 more
doaj   +1 more source

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