Results 141 to 150 of about 1,944,890 (372)
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
PKQuest: PBPK modeling of highly lipid soluble and extracellular solutes
ADMET and DMPK, 2019 One of the primary objectives of physiologically based pharmacokinetics (PBPK) is the prediction of a drug’s pharmacokinetics just from knowledge of its physicochemical structure.
David G. Levitt
doaj +1 more source
Dynamics of the brain extracellular matrix governed by interactions with neural cells [PDF]
arXiv, 2018 Neuronal and glial cells release diverse proteoglycans and glycoproteins, which aggregate in the extracellular space and form the extracellular matrix (ECM) that may in turn regulate major cellular functions. Brain cells also release extracellular proteases that may degrade the ECM, and both synthesis and degradation of ECM are activity-dependent.
arxiv
THE EXTRACELLULAR RELATION OF THE MALARIAL PARASITE TO THE RED CORPUSCLE, AND ITS METHOD OF SECURING ATTACHMENT TO THE EXTERNAL SURFACE OF THE RED CORPUSCLE [PDF]
, 1913 Mary Rowley-Lawson
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Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Nano Biomedicine and Engineering, 2012 In the current study, various endophytic bacterial isolates from Piper nigrum were explored for its nanoparticle synthesizing property. Very interestingly, one of the isolate which is a strain of Bordetella sp.
Roshmi Thomas +3 more
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AN ANTIDIURETIC MECHANISM NOT REGULATED BY EXTRACELLULAR FLUID TONICITY 12 [PDF]
, 1952 Alexander Leaf, Audley R. Mamby
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Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source