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Nonlinear regression modeling of ruminal fermentation dynamics in buffered diets using in vitro gas production. [PDF]

PLoS One
Asadollahi Seyedabadi Z, Danesh Mesgaran M, Rohani A, Vakili SA.   +3 more
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Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis

Journal of Cardiovascular Electrophysiology, 2011
Human ether-à-go-go related gene (hERG) is responsible for channels that mediate the rapid delayed rectifier K(+) channel current (I(Kr) ), which participates in repolarization of the ventricles and is a target for some antiarrhythmic drugs. Acidosis occurs in the heart in some pathological situations and can modify the function and responses to drugs ...
, J C Hancox
exaly   +4 more sources

The Impact of Extracellular Acidosis on Dendritic Cell Function

Critical Reviews in Immunology, 2004
Dendritic cells (DCs) are the most efficient antigen-presenting cells. They are activated in the periphery by conserved pathogen molecules and by inflammatory mediators produced by a variety of cell types in response to danger signals. It is widely appreciated that inflammatory responses in peripheral tissues are usually associated with the development
Mónica Elba, Vermeulen, Romina, Gamberale, Analía Silvina, Trevani, Diego, Martínez, Ana, Ceballos, Juan, Sabatte, Mirta, Giordano, Jorge Raúl, Geffner   +7 more
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Extracellular acidosis modulates the endocytosis and maturation of macrophages

Cellular Immunology, 2013
Extracellular acidosis is involved in various pathological situations of central nervous system and the effects are largely mediated by acid sensing ion channels (ASICs). However, it remains unclear whether extracellular acidosis affects immune cells. Macrophages are immune cells that play important role in immune reactions.
Xiaoling, Kong, Xianying, Tang, Wenjiao, Du, Jing, Tong, Yutao, Yan, Fang, Zheng, Min, Fang, Feili, Gong, Zheng, Tan   +8 more
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Extracellular acidosis results in higher intracellular acidosis and greater contraction in spontaneously hypertensive rat aorta

European Journal of Pharmacology, 2003
Acidic pH induces a contraction in aorta from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. The contractile response to acidic pH in SHR aorta is greater than that in WKY aorta. The purpose of this study was to investigate the correlation among extracellular pH (pH(o)), intracellular pH (pH(i)) and contraction in order to understand the
Dileep Kumar, Rohra, Shin-ya, Saito, Yasushi, Ohizumi   +2 more
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Effect of intracellular and extracellular acidosis on sodium current in ventricular myocytes

American Journal of Physiology-Heart and Circulatory Physiology, 1995
Conduction slowing is an essential element in the generation of ischemic ventricular arrhythmias and is determined in part by the inward Na+ current (INa). Because intracellular acidosis is an early consequence of ischemia, we hypothesized that lowering intracellular pH (pHi) would reduce or kinetically modulate INa and thus affect cardiac conduction.
C L, Watson, M R, Gold
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The effect of extracellular calcium and preload on a teleost heart during extracellular hypercapnic acidosis

Canadian Journal of Zoology, 1984
The effect of extracellular calcium ([Ca2+]e) on the performance of the in situ perfused sea raven heart was evaluated under nonacidotic, acidotic, and high work load conditions. Increases in [Ca2+]e improved power output of the nonacidotic heart and restored control levels of power output to the heart exposed to hypercapnic acidosis (1.8% CO2, pH 7.4)
A. P. Farrell, T. Hart, S. Wood, W. R. Driedzic   +3 more
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