Results 181 to 190 of about 28,000 (215)

Varying Role of Extracellular Electrolytes in Metabolic Acidosis and Alkalosis

American Journal of Physiology-Legacy Content, 1958
The responses of plasma and extracellular space to different types of acids and alkalis were studied in nephrectomized cats. Compensation for mineral acids can largely be accounted for by changes which are detectable in extracellular constituents. These changes are movement of Na+ and K+ into the extracellular space (ECS) and loss of HCO3– from the ...
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Abstract 3213: Extracellular acidosis alters polarization of macrophages

Cancer Research, 2015
Abstract Deficits in tumor perfusion and elevated glycolysis combine to reduce the pH of the tumor microenvironment. In poorly perfused volumes, oxygen and nutrient deprivation may also elicit necrotic areas that trigger infiltration of immune cells, including tumor-associated macrophages (TAMs). Inside tumors, TAMs are biased towards an
Asmaa E. El-Kenawi, Arig A. Ibrahim-Hashim, Kimberly A. Luddy, Shari A. Pilon-Thomas, Robert A. Gatenby, Robert J. Gillies   +5 more
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Extracellular Acidosis and Cancer

2014
Solid tumours acidify their interstitial fluid by a number of diverse processes that result in net proton export. These include activity of monocarbonate and bicarbonate transporters, V-type ATPases, carbonic anhydrases and voltage-gated proton channels.
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Extracellular mild acidosis decreases the Ca2+ permeability of the human NMDA receptors

Cell Calcium, 2019
NMDA receptors (NMDARs) are glutamate-gated ion channels involved in excitatory synaptic transmission and in others physiological processes such as synaptic plasticity and development. The overload of Ca2+ ions through NMDARs, caused by an excessive activation of receptors, leads to excitotoxic neuronal cell death. For this reason, the reduction of Ca2+
Plutino S., Sciaccaluga M., Fucile S.
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Mouse colon sensory neurons detect extracellular acidosis via TRPV1

American Journal of Physiology-Cell Physiology, 2007
Extracellular acidification contributes to pain by activating or modulating nociceptor activity. To evaluate acidic signaling from the colon, we characterized acid-elicited currents in thoracolumbar (TL) and lumbosacral (LS) dorsal root ganglion (DRG) neurons identified by content of a fluorescent dye (DiI) previously injected into the colon wall.
Takeshi, Sugiura, Klaus, Bielefeldt, G F, Gebhart   +2 more
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Extracellular Acidosis Regulates the Expression of Inflammatory Mediators in Rat Epithelial Cells

2020
Acidification of the cellular microenvironment is found in different pathological states such as inflammation, ischemia and in solid tumors. It can affect cell function and phenotype, and by this aggravate the pathological process. Epithelial cells are a relevant functional part in several normal organs as well as in tumors and will thus be challenged ...
A, Riemann, S, Reime, M, Gießelmann, O, Thews   +3 more
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Role of the mTOR Signalling Pathway During Extracellular Acidosis in Tumour Cells

2022
The metabolic microenvironment of solid tumours is often dominated by extracellular acidosis which results from glycolytic metabolism. Acidosis can modulate gene expression and foster the malignant progression. The aim of the study was to analyse the effects of extracellular acidosis on the mTOR signalling pathway, an important regulator of anabolic ...
M, Wolff, M, Rauschner, S, Reime, A, Riemann, O, Thews   +4 more
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Plasma, Extracellular and Muscle Electrolyte Responses to Acute Metabolic Acidosis

American Journal of Physiology-Legacy Content, 1956
Nephrectomized cats were infused with hydrochloric acid in loads of from 3.5–9.6 mEq/kg. Extracellular moderation of the acidosis calculated from concentrations of electrolytes in plasma and inulin volumes of distribution was proportioned as follows: 35% by Na and 5% by K entering the ECS, and 20% by Cl and 24% by CO2 leaving the ECS.
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Disparate effects of three types of extracellular acidosis on left ventricular function

American Journal of Physiology-Heart and Circulatory Physiology, 1999
Effects of acidosis on muscle contractile function have been studied extensively. However, the relative effects of different types of extracellular acidosis on left ventricular (LV) contractile function, especially the temporal features of contraction, have not been investigated in a single model.
D S, Berger, S K, Fellner, K A, Robinson, K, Vlasica, I E, Godoy, S G, Shroff   +5 more
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Extracellular Acidosis Modulates Drug Block of Kv4.3 Currents by Flecainide and Quinidine

Journal of Cardiovascular Electrophysiology, 2003
Introduction: As a molecular model of the effect of ischemia on drug block of the transient outward potassium current, the effect of acidosis on the blocking properties of flecainide and quinidine on Kv4.3 currents was studied. Methods and Results: Kv4.3 channels were stably expressed in Chinese hamster ovary cells.
Suresh, Singarayar, Jane, Bursill, Ken, Wyse, Asne, Bauskin, Wan, Wu, Jamie, Vandenberg, Samuel, Breit, Terence, Campbell   +7 more
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