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A Genomic Analysis of Cellular Responses and Adaptions to Extracellular Acidosis
2014Even though lactic acidosis is a prominent feature of solid tumors, we have limited understanding of the mechanisms by which lactic acidosis influences the genetic, epigenetic, proteomic, and metabolic phenotypes of cancer cells. This chapter aims to (1) briefly outline the tumor microenvironment and how acidity relates to its biology; (2) briefly ...
Melissa M. Keenan +2 more
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Brain Tissue Acidosis: Effects on the Extracellular Concentration of N‐Acetylaspartate
Journal of Neurochemistry, 1997Abstract: N‐Acetylaspartate (NAA) is characterized by a high tissue‐to‐extracellular concentration ratio under normal conditions and is released from neurons during hyposmotic cell swelling. As cell volume regulation and acid‐base homeostasis share common processes, we have examined by microdialysis whether the extracellular concentration of NAA is ...
M, Gotoh, S E, Davies, T P, Obrenovitch
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Extracellular acidosis minimizes actin cytoskeletal alterations during ATP depletion
American Journal of Physiology-Renal Physiology, 1994Extracellular acidosis has been shown to be protective during ischemia in renal tubule cells. However, the mechanism of protection remains unknown. Since ischemia leads to disruption and polymerization of the cortical actin cytoskeleton, we hypothesized acidosis may better preserve the actin cytoskeleton during ischemia.
E M, Fish, B A, Molitoris
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Effect of extracellular acidosis on 45Ca uptake in isolated hypoxic proximal tubules
American Journal of Physiology-Cell Physiology, 1988Recent in vitro studies have suggested that the presence of extracellular acidosis is protective against the development of oxygen-deprivation injury in several tissues. Because cellular Ca accumulation after renal ischemia may represent a major pathogenic event leading to cellular damage, the purpose of the present study was to examine the effect of ...
M, Burnier +3 more
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Influence of Extracellular Acidosis on Matrix Protein Homeostasis in Tumour Cells and Fibroblasts
2018Pathogenesis of tumour development comprises among others changes of its microenvironment that can be caused by tumour cells or stroma cells like fibroblasts and include extracellular acidosis. Acidosis then may have impact on tumour cells, fibroblasts and their cross-talk, leading for example to an altered matrix protein homeostasis.
M-C, Schulz +3 more
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Journal of Neuroscience Research, 1994
AbstractMicrodialysis‐perfusion of the urethane‐anesthetized rat hippocampus was performed to assess the effects of acidosis on extracellular amino acids. Perfusion with Krebs‐Ringer bicarbonate buffer at pH 6.9 produced a selective decrease in taurine. A further reduction of pH to 6.4 induced diminished glutamate levels.
M, Puka, A, Lehmann
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AbstractMicrodialysis‐perfusion of the urethane‐anesthetized rat hippocampus was performed to assess the effects of acidosis on extracellular amino acids. Perfusion with Krebs‐Ringer bicarbonate buffer at pH 6.9 produced a selective decrease in taurine. A further reduction of pH to 6.4 induced diminished glutamate levels.
M, Puka, A, Lehmann
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Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes
American Journal of Physiology-Cell Physiology, 1988A fluorometric assay using propidium iodide total fluorescence was utilized to quantitate cell viability in hepatocyte suspensions continuously. For viable hepatocytes exposed to KCN, fluorescence was linearly proportional to lactate dehydrogenase release and to nuclear labeling by propidium iodide.
G J, Gores +5 more
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Triple-edged therapy targeting intracellular alkalosis and extracellular acidosis in cancer
Seminars in Cancer Biology, 2017Extracellular acidity and intracellular alkalinity are two of the characteristics hallmarks of malignant cells and their environment. This involves an inversion of the extracellular/intracellular pH gradient when compared with normal cells and it gives malignant cells proliferative and invasive advantages.
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2018
Under pathological conditions like inflammation, ischemia or in solid tumors, parameters of the microenvironment like local oxygenation and extracellular pH show marked changes when compared to healthy tissue. The altered microenvironment affects cellular phenotype of omnipresent fibroblasts and immune cells.
A, Riemann +5 more
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Under pathological conditions like inflammation, ischemia or in solid tumors, parameters of the microenvironment like local oxygenation and extracellular pH show marked changes when compared to healthy tissue. The altered microenvironment affects cellular phenotype of omnipresent fibroblasts and immune cells.
A, Riemann +5 more
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Extracellular acidosis triggers a senescence‐like phenotype in human melanoma cells
Pigment Cell and Melanoma Research, 2020Anja Bosserhoff
exaly