Results 41 to 50 of about 28,000 (215)

Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. [PDF]

PLoS ONE, 2013
Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood perfusion. However, the molecular
Lixue Dong, Zhigang Li, Nancy R Leffler, Adam S Asch, Jen-Tsan Chi, Li V Yang   +5 more
doaj   +1 more source

Acidic environment leads to ROS-induced MAPK signaling in cancer cells. [PDF]

PLoS ONE, 2011
Tumor micromilieu often shows pronounced acidosis forcing cells to adapt their phenotype towards enhanced tumorigenesis induced by altered cellular signalling and transcriptional regulation.
Anne Riemann, Bettina Schneider, Angelika Ihling, Martin Nowak, Christoph Sauvant, Oliver Thews, Michael Gekle   +6 more
doaj   +1 more source

Effects of Hypoxia and Acidosis on Cardiac Electrophysiology and Hemodynamics. Is NHE-Inhibition by Cariporide Still Advantageous?

Frontiers in Physiology, 2020
Hypoxia often leads to severe cardiac malfunctions. It is assumed that intracellular calcium overload is -inter alia- responsible for left ventricular (LV) deterioration.
Aida Salameh, Helena Zöbisch, Bianca Schröder, Jonas Vigelahn, Mandy Jahn, Getu Abraham, Johannes Seeger, Ingo Dähnert, Stefan Dhein   +8 more
doaj   +1 more source

Proton Quantum Tunneling: Influence and Relevance to Acidosis-Induced Cardiac Arrhythmias/Cardiac Arrest

Pathophysiology, 2021
Acidosis and its associated pathologies predispose patients to develop cardiac arrhythmias and even cardiac arrest. These arrhythmias are assumed to be the result of membrane depolarization, however, the exact mechanism of depolarization during acidosis ...
Omar Ababneh, Abdallah Barjas Qaswal, Ahmad Alelaumi, Lubna Khreesha, Mujahed Almomani, Majdi Khrais, Oweiss Khrais, Ahmad Suleihat, Shahed Mutleq, Yazan Al-olaimat, Sager Nawafleh   +10 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Acidosis inhibits rhythmic contractions of human thoracic ducts

Physiological Reports, 2019
Lymph vessels counteract edema by transporting interstitial fluid from peripheral tissues to the large veins and serve as conduits for immune cells, cancer cells, and pathogens.
Anders L. Moeller, Vibeke E. Hjortdal, Donna M. B. Boedtkjer, Ebbe Boedtkjer   +3 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Tumor Microenvironment Modulates Invadopodia Activity of Non-Selected and Acid-Selected Pancreatic Cancer Cells and Its Sensitivity to Gemcitabine and C18-Gemcitabine

Cells
Background: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with high mortality due to early metastatic dissemination and high chemoresistance.
Tiago M. A. Carvalho, Madelaine Magalì Audero, Maria Raffaella Greco, Marilena Ardone, Teresa Maggi, Rosanna Mallamaci, Barbara Rolando, Silvia Arpicco, Federico Alessandro Ruffinatti, Alessandra Fiorio Pla, Natalia Prevarskaya, Tomas Koltai, Stephan J. Reshkin, Rosa Angela Cardone   +13 more
doaj   +1 more source

Identification of distinct slow mode of reversible adaptation of pancreatic ductal adenocarcinoma to the prolonged acidic pH microenvironment

Journal of Experimental & Clinical Cancer Research, 2022
Background Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm with high metastatic potential and poor clinical outcome. Like other solid tumors, PDAC in the early stages is often asymptomatic, and grows very slowly under a ...
Tzu-Chin Wu, Chien-Yu Liao, Wei-Chien Lu, Chuang-Rung Chang, Fang-Yu Tsai, Shih-Sheng Jiang, Tsung-Hsien Chen, Kurt Ming-Chao Lin, Li-Tzong Chen, Wun-Shaing Wayne Chang   +9 more
doaj   +1 more source