Results 31 to 40 of about 28,000 (215)

Does the ventricle limit cardiac contraction rate in the anoxic turtle (Trachemys scripta)? I. Comparison of the intrinsic contractile responses of cardiac chambers to the extracellular changes that accompany prolonged anoxia exposure

Current Research in Physiology, 2022
Multiple lines of evidence suggest that an inability of the ventricle to contract in coordination with the pacemaker during anoxia exposure may suppress cardiac pumping rate in anoxia-tolerant turtles. To determine under what extracellular conditions the
Molly Garner, Jonathan A.W. Stecyk
doaj   +1 more source

The Influence of Extracellular Acidosis on the Effect of IKr Blockers

Journal of Cardiovascular Pharmacology and Therapeutics, 2005
Background: Myocardial infarction causes the acidification of the cellular environment and the resultant acidosis maybe arrhythmogenic. The effect of acidosis on the action of antiar-rhythmic drugs, an important issue in the antiarrhythmic drug therapy after myocardial infarction, remains to be studied. Methods: To evaluate the effect
Congrong, Lin, Xiaogang, Ke, Ivana, Cvetanovic, Vasant, Ranade, John, Somberg   +4 more
openaire   +2 more sources

Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis [PDF]

The Journal of Neuroscience, 2011
Ischemic brain injury is a major problem associated with stroke. It has been increasingly recognized that acid-sensing ion channels (ASICs) contribute significantly to ischemic neuronal damage, but the underlying mechanism has remained elusive. Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal ...
Bo, Duan, Yi-Zhi, Wang, Tao, Yang, Xiang-Ping, Chu, Ye, Yu, Yu, Huang, Hui, Cao, Jillian, Hansen, Roger P, Simon, Michael X, Zhu, Zhi-Gang, Xiong, Tian-Le, Xu   +11 more
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Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity.

PLoS ONE, 2015
BackgroundAcidosis impairs cognitions and behaviors presumably by acidification-induced changes in neuronal metabolism. Cortical GABAergic neurons are vulnerable to pathological factors and their injury leads to brain dysfunction.
Li Huang, Shidi Zhao, Wei Lu, Sudong Guan, Yan Zhu, Jin-Hui Wang   +5 more
doaj   +1 more source

Combating muscle fatigue: extracellular lactic acidosis and catecholamines [PDF]

The Journal of Physiology, 2007
During strenuous exercise, contracting skeletal muscle fatigues at a high rate in part due to ionic imbalances occurring across the sarcolemma that contribute to decreased sarcolemmal excitatibility (Sjogaard, 1990). It is suspected that the reduced excitability contributes to a reduction in calcium release by the sarcoplasmic reticulum and a ...
openaire   +2 more sources

Differential metabolic responses in breast cancer cell lines to acidosis and lactic acidosis revealed by stable isotope assisted metabolomics

Scientific Reports, 2020
Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis. Acidosis and lactic acidosis can induce different responses in tumors. Previous
Jiayue Gao, Zhiying Guo, Jianhua Cheng, Bo Sun, Jie Yang, Haijing Li, Shengming Wu, Fangting Dong, Xianzhong Yan   +8 more
doaj   +1 more source

Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies

Journal of Translational Medicine, 2017
Background Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism.
Calvin R. Justus, Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong, Li V. Yang   +6 more
doaj   +1 more source

pHLuc, a Ratiometric Luminescent Reporter for in vivo Monitoring of Tumor Acidosis

Frontiers in Bioengineering and Biotechnology, 2020
Even under normoxia, cancer cells exhibit increased glucose uptake and glycolysis, an occurrence known as the Warburg effect. This altered metabolism results in increased lactic acid production, leading to extracellular acidosis and contributing to ...
Tiffany T. Ong, Zhiwei Ang, Riva Verma, Ricky Koean, John Kit Chung Tam, Jeak Ling Ding   +5 more
doaj   +1 more source

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia

Frontiers in Oncology, 2020
Tumor hypoxia represents a severe microenvironmental stress that is frequently associated with acidosis. Cancer cells respond to these stresses with changes in gene expression that promote survival at least in part through pH regulation and metabolic ...
Martin Benej, Martin Benej, Eliska Svastova, Radivojka Banova, Juraj Kopacek, Adriana Gibadulinova, Martin Kery, Simona Arena, Andrea Scaloni, Monica Vitale, Monica Vitale, Nicola Zambrano, Nicola Zambrano, Ioanna Papandreou, Nicholas C. Denko, Silvia Pastorekova   +15 more
doaj   +1 more source

Intracellular pH During Metabolic Acidosis of Intracellular and Extracellular Origin.

Experimental Biology and Medicine, 1967
SummaryIntracellular pH was determined by distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO) in skeletal muscle of dogs 1) infused with .3 N HCl, 2) infused with .3 N gluconic acid, 3) infused with HCl and hyperventilated to maintain extracellular fluid pH constant, 4) infused with .6 N HCO3 and given CO2 and O2 to breathe to maintain ...
E B, Brown, W G, Kim, F A, Moorhead
openaire   +2 more sources