Results 21 to 30 of about 28,000 (215)
PLoS ONE, 2023 Extracellular pH is an important parameter influencing cell function and fate. Microenvironmental acidosis accompanies different pathological situations, including inflammation, hypoxia and ischemia.
Virginie Dubourg +5 more
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The Effects of Extracellular Acidosis on Neurons and Glia in vitro [PDF]
Journal of Cerebral Blood Flow & Metabolism, 1989 Cerebral lactic acid, a product of ischemic anaerobic glycolysis, may directly contribute to ischemic brain damage in vivo. In this study we evaluated the effects of extracellular acid exposure on 7-day-old cultures of embryonic rat forebrain. Mixed neuronal and glial cultures were exposed to either lactic or hydrochloric acid to compare the toxicities
S A, Goldman +4 more
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BMC Cancer, 2022 Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the cancer, and tumor acidosis has been shown to inhibit the activity of immune cells ...
Yong-Jin Kwon +11 more
doaj +1 more source
Pathophysiological aspect of metabolic acid-base disorders [PDF]
Medicinski Podmladak, 2016 Maintaing the arterial pH values (in normal range of 7,35-7,45) is one of the main principles of homeostasis. Regulatory responses, including chemical buffering (extracellular, intracellular, sceletal), the regulation of pCO2 by the respiratory system ...
Nešović-Ostojić Jelena
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Chinese Journal of Physiology, 2022 Ca2+-sensing receptors (CaSRs) are G protein-coupled receptors activated by elevated concentrations of extracellular Ca2+. In our previous works, we showed protein and functional expression of CaSR in mouse cerebral endothelial cell (EC) (bEND.3); the ...
Iat-Lon Leong +5 more
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Biomedicines, 2022 Pathogenesis of chronic kidney disease (CKD) is accompanied by extracellular acidosis inflammation, fibrosis and epithelial-to-mesenchymal transition (EMT). The aim of this study was to assess the influence of acidosis on tubule epithelial cells (NRK-52E)
Marie-Christin Schulz +3 more
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Extracellular acidosis impairs P2Y receptor-mediated Ca2+ signalling and migration of microglia [PDF]
Cell Calcium, 2015 Maike Glitsch
exaly +2 more sources
Antioxidants, 2023 Crosstalk of renal epithelial cells with interstitial fibroblasts plays an important role in kidney pathophysiology. A previous study showed that crosstalk between renal epithelial cells and renal fibroblasts protects against acidosis-induced damage.
Marie-Christin Schulz +5 more
doaj +1 more source
Glial swelling during extracellular acidosis in vitro. [PDF]
Stroke, 1988 Intracellular and extracellular acidosis may determine the ultimate outcome for brain tissue in cerebral ischemia. An extracellular acidosis that occurs in the penumbra zone was investigated in vitro as to its role in the formation of cytotoxic cell swelling.
O, Kempski +4 more
openaire +2 more sources
Cells, 2022 Bone is the most common site of metastasis in breast cancer. Metastasis is promoted by acidosis, which is associated with osteoporosis. To investigate how acidosis could promote bone metastasis, we compared differentially expressed genes (DEGs) in MDA-MB-
Ana Sayuri Yamagata +6 more
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