Results 11 to 20 of about 28,000 (215)

Extracellular pH in the Brain during Ischemia: Relationship to the Severity of Lactic Acidosis [PDF]

Journal of Cerebral Blood Flow and Metabolism, 1991
On the basis of data showing a bimodal distribution of values for extracellular pH (pH e ), and a discontinuous ΔPco 2 /Δlactate relationship, Kraig et al.
A Ekholm, Anders Ekholm, K Katsura
exaly   +3 more sources

Selective vulnerability of cultured cortical glia to injury by extracellular acidosis

Brain Research, 1990
Reduction of extracellular pH from 7.4 to 6.5 attenuated glutamate neurotoxicity in murine cortical neuronal and glial cultures, but if maintained for 24 h, resulted in morphological evidence of selective glial injury. Acid-induced gliotoxicity was examined quantitatively in cortical astrocyte cultures, using lactate dehydrogenase efflux as an index of
R G Giffard, Hannelore Monyer, Dennis W Choi   +2 more
exaly   +3 more sources

Acidosis Drives Vasculogenic Mimicry in PDAC CSCs via Na+/H+ Exchanger Isoform 1 (NHE1) and Calcium Entry [PDF]

Cells
Vasculogenic mimicry (VM) is the ability of cancer stem cells (CSCs) to express an endothelial-like phenotype and participate in tumor neovascularization via the formation of a blood-conducting, matrix-rich network. We previously reported that pancreatic
Maria Raffaella Greco, Francesca Fracasso, Stefania Cannone, Daria Di Molfetta, Marilena Ardone, Sharon Natasha Cox, Brunella Rita Ladogana, Daniela Isabel Abbrescia, Apollonia Tullo, Marianna Ranieri, Stephan J. Reshkin, Rosa Angela Cardone   +11 more
doaj   +2 more sources

Sodium bicarbonate for “metabolic acidosis”: an illustration of the Goodhart’s law [PDF]

Journal of Intensive Care
Background Correction of “metabolic acidosis” by sodium bicarbonate is a common practice in intensive care unit or operating room. The physiological rationale underlying its use relies on the potential harmful hemodynamics effects of prolonged low ...
Sylvain Diop, Maxime Aparicio, Roman Mounier, Antoine Premachandra   +3 more
doaj   +2 more sources

Hypoxia restores the acidosis-induced inhibition of cancer cell dissemination [PDF]

Cell Reports
Summary: Acidosis is a hallmark of the tumor microenvironment and has been linked to aggressive cancer behavior, characterized by increased migration, invasion, and metastasis.
Se Jong Lee, Alice Amitrano, Qinling Yuan, Debanik Choudhury, Konstantin Stoletov, Bhawana Agarwal, Avery Tran, Inês Godet, James McCann, Ryan Huizar, Selma A. Serra, Pol Picón-Pagès, Norbert Valles, Sangmoo Jeong, Stavroula Sofou, Chen-Ming Fan, John D. Lewis, Sean X. Sun, Andrew J. Ewald, Daniele M. Gilkes, Vivek K. Bajpai, Miguel A. Valverde, Konstantinos Konstantopoulos   +22 more
doaj   +2 more sources

Lysosomal protein relocation as an adaptation mechanism to extracellular acidosis. [PDF]

Cell Cycle, 2016
Damaghi M, Gillies RJ.
europepmc   +4 more sources

The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation [PDF]

Brain, Behavior, and Immunity, 2021
Long-Jun Wu, Rodney Ritzel, Simon Liu
exaly   +2 more sources

Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.

Am J Physiol Cell Physiol, 2016
Activation of β-platelet-derived growth factor receptor (β-PDGFR) is associated with prostate cancer (PCa) progression and recurrence after prostatectomy. Analysis of the β-PDGFR ligands in PCa revealed association between PDGF-D expression and Gleason score as well as tumor stage.
Najy AJ, Dyson G, Jena BP, Lin CY, Kim HR.   +4 more
europepmc   +4 more sources

Effects of extracellular metabolic acidosis on the homeostasis of intracellular pH in hippocampal neurons

Frontiers in Physiology
This Hypothesis & Theory contribution accompanies the research paper by Bouyer et al. (Frontiers in Physiology 2024), the first to employ out-of-equilibrium (OOE) CO2/HCO3− solutions to examine systematically the intracellular pH (pHi) effects of ...
Patrice G. Bouyer, Rossana Occhipinti, Rossana Occhipinti, Sara Taki, Fraser J. Moss, Walter F. Boron   +5 more
doaj   +3 more sources

An acidic microenvironment in Tuberculosis increases extracellular matrix degradation by regulating macrophage inflammatory responses.

PLoS Pathogens, 2023
Mycobacterium tuberculosis (M.tb) infection causes marked tissue inflammation leading to lung destruction and morbidity. The inflammatory extracellular microenvironment is acidic, however the effect of this acidosis on the immune response to M.tb is ...
Ashley M Whittington, Frances S Turner, Friedrich Baark, Sam Templeman, Daniela E Kirwan, Candice Roufosse, Nitya Krishnan, Brian D Robertson, Deborah L W Chong, Joanna C Porter, Robert H Gilman, Jon S Friedland   +11 more
doaj   +1 more source