Regulation of Tumor Metabolism and Extracellular Acidosis by the TIMP-10–CD63 Axis in Breast Carcinoma [PDF]
Cells, 2021 A hallmark of malignant solid tumor is extracellular acidification coupled with metabolic switch to aerobic glycolysis. Using the human MCF10A progression model of breast cancer, we show that glycolytic switch and extracellular acidosis in aggressive ...
Abdo J. Najy +4 more
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Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract [PDF]
Emerging Microbes and Infections, 2021 Zika virus (ZIKV) is a flavivirus transmitted by mosquitoes of the genus Aedes, but unlike other flaviviruses, ZIKV can be sexually transmitted by vaginal intercourse.
A. Varese +14 more
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Modulation of mitochondrial function by extracellular acidosis in tumor cells and normal fibroblasts: Role of signaling pathways [PDF]
Neoplasia: An International Journal for Oncology ResearchIn many tumors pronounced extracellular acidosis resulting from glycolytic metabolism is found. Since several environmental stress factors affect the mitochondrial activity the aim of the study was to analyze the impact of acidosis on cellular oxygen ...
Carmen Degitz +4 more
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TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis [PDF]
Cell Death Discovery, 2021 Extracellular acidosis-induced mitochondrial damage of cardiomyocytes leads to cardiac dysfunction, but no detailed mechanism or efficient therapeutic target has been reported.
Lingxiao Zhang +4 more
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Motility and Mechanical Properties of Dendritic Cells Deteriorated by Extracellular Acidosis. [PDF]
Inflammation, 2021 Abstract Dendritic cells (DCs) are the most powerful antigen-presenting cells known to date and play an important role in initiating and amplifying both innate and adaptive immune responses. Extracellular acidosis is an important hallmark of a variety of inflammatory processes and solid tumors. However, few
Tong L +5 more
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Unravelling the Interplay between Extracellular Acidosis and Immune Cells. [PDF]
Mediators Inflamm, 2018 The development of an acidic tissue environment is a hallmark of a variety of inflammatory processes and solid tumors. However, little attention has been paid so far to analyze the influence exerted by extracellular pH on the immune response. Tissue acidosis (pH 6.0 to 7.0) is usually associated with the course of infectious processes in peripheral ...
Erra Díaz F, Dantas E, Geffner J.
europepmc +5 more sources
Cells, 2023 Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e.g., endothelial cells, fibroblasts, and immune ...
Elena Andreucci +7 more
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The effect of extracellular acidosis on the behaviour of mesenchymal stem cells in vitro [PDF]
European Cells & Materials, 2017 The stem cell fraction of a cell population is finely tuned by stimuli from the external microenvironment. Among these stimuli, a decrease of extracellular pH (pHe) may occur in a variety of physiological and pathological conditions, including hypoxia ...
A Massa +6 more
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Extracellular acidosis differentiates pancreatitis and pancreatic cancer in mouse models using acidoCEST MRI [PDF]
Neoplasia: An International Journal for Oncology Research, 2019 Differentiating pancreatitis from pancreatic cancer would improve diagnostic specificity, and prognosticating pancreatitis that progresses to pancreatic cancer would also improve diagnoses of pancreas pathology.
Rachel A. High +7 more
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Tumor-derived sphingosine-1-phosphate shapes angiogenesis in the acidic microenvironment of osteosarcoma via paracrine and autocrine signaling [PDF]
Frontiers in Cell and Developmental BiologyIntroductionTumor-associated angiogenesis is a critical driver of tumor progression and is frequently characterized by excessive branching and structural disorganization.
Sofia Avnet +7 more
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