Results 31 to 40 of about 302,924 (260)

c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells ^†

Cells, 2020
Angiogenic vasa vasorum (VV) expansion plays an essential role in the pathogenesis of hypoxia-induced pulmonary hypertension (PH), a cardiovascular disease.
Derek Strassheim, Vijaya Karoor, Hala Nijmeh, Philip Weston, Martin Lapel, Jerome Schaack, Timothy Sullivan, Edward C. Dempsey, Kurt R. Stenmark, Evgenia Gerasimovskaya   +9 more
doaj   +1 more source

Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2016
Adenosine triphosphate (ATP) plays an important role as a primary molecule for the transfer of chemical energy to drive biological processes. ATP also functions as an extracellular signaling molecule in a diverse array of eukaryotic taxa in a conserved ...
Theodore W. Peters, Aaron W. Miller, Cendrine Tourette, Hannah Agren, Alan Hubbard, Robert E. Hughes   +5 more
doaj   +1 more source

Release of ATP from marginal cells in the cochlea of neonatal rats can be induced by changes in extracellular and intracellular ion concentrations. [PDF]

PLoS ONE, 2012
BackgroundAdenosine triphosphate (ATP) plays an important role in the cochlea. However, the source of ATP and the mechanism by which it is released remain unclear.
Yating Peng, Jie Chen, Shan He, Jun Yang, Hao Wu   +4 more
doaj   +1 more source

Simultaneous Fluorescent Recordings of Extracellular ATP and Intracellular Calcium in Mammalian Cells

Bio-Protocol, 2019
Extracellular ATP is a potent signaling molecule that stimulates intracellular calcium responses through purinergic (P2) receptors in mammalian cells. While extracellular ATP and intracellular calcium can be measured separately, simultaneous monitoring ...
Nicholas Mikolajewicz, Svetlana Komarova
doaj   +1 more source

Homeostasis of Extracellular ATP in Human Erythrocytes [PDF]

Journal of Biological Chemistry, 2011
استكشفنا العمليات داخل وخارج الخلايا التي تحكم حركية ATP خارج الخلايا (ATPe) في كريات الدم الحمراء البشرية المحفزة بالعوامل التي تزيد من المخيم. باستخدام تفاعل لوسيفيرين- لوسيفيراز في قياس الإضاءة خارج الخط، وجدنا تنشيطًا مباشرًا لأنزيم الأدينيل سايكلز بواسطة فورسكولين وتنشيطًا غير مباشر من خلال التحفيز الأدرينالي بيتا مع [ATP]e المعزز بالإيزوبروتينول ...
Nicolás Montalbetti, María Florencia Leal Denis, Omar P. Pignataro, Eiry Kobatake, Eduardo R. Lazarowski, Pablo J. Schwarzbaum   +5 more
openaire   +2 more sources

Extracellular ATP and P2X7 receptors in neurodegeneration

European Journal of Pharmacology, 2002
Neuronal injury and cell death in the central nervous system (CNS) are underlying features of neurodegenerative disorders. However, our understanding of the fundamental mechanisms involved is still limited. Inflammatory processes mediated by cytokines, and interleukin-1 (IL-1) in particular, play a significant role in neuronal death following ...
Le Feuvre, Rosalind; id_orcid 0000-0002-9817-9904, Brough, David; id_orcid 0000-0002-2250-2381, Rothwell, Nancy   +2 more
openaire   +3 more sources

Hepatocyte heterogeneity in response to extracellular ATP [PDF]

European Journal of Biochemistry, 1987
The metabolic and hemodynamic effects of extracellular ATP in perfused rat liver were compared during physiologically antegrade (portal to hepatic vein) and retrograde (hepatic to portal vein) perfusion. ATP in concentrations up to 100 μM was completely hydrolyzed during a single liver passage regardless of the perfusion direction.
D, Häussinger, T, Stehle, W, Gerok, T A, Tran-Thi, K, Decker   +4 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Dark Side of Extracellular ATP in Kidney Diseases [PDF]

Journal of the American Society of Nephrology, 2015
Intracellular ATP is the most vital source of cellular energy for biologic systems, whereas extracellular ATP is a multifaceted mediator of several cell functions via its interaction, in an autocrine or paracrine manner, with P2 purinergic receptors expressed on the cell surface.
SOLINI, ANNA, Usuelli V, Fiorina P.
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source