Results 101 to 110 of about 1,499,817 (257)

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

ADAMTS7 extracellular matrix enzyme expression is required for optimal influenza-specific CD8+T cell immunity

, 2018
ADAMTS7 extracellular matrix enzyme expression is required for optimal influenza-specific CD8+T cell ...
Meagan McMahon (7827716), Siying Ye (13094898), Ralph A Tripp (13500649), Daniel Dlugolenski (13066383), Daniel McCulloch (13562389), John Stambas (13077333)   +5 more
core  

Extracellular cellulolytic enzyme profiles of five lignicolous mangrove fungi

, 1999
Five lignicolous mangrove fungi (Hypoxlon oceanicum, Julella avicenniae, Lignincola laevis, Savoryella lignicola and Trematosphaeria mangrovei) produced extracellular endoglucanase cellobiohydrolase and β-glucosidase when cultivated under static ...
Jones, EBG, Pointing, SB, Buswell, JA, Vrijmoed, LLP   +3 more
core   +1 more source

Microbial Metabolic Limitations and Their Relationships with Sediment Organic Carbon Across Lake Salinity Gradient in Tibetan Plateau

Microorganisms
Inland lakes, contributing substantially to the global storage of sediment organic carbon (SOC), are subject to marked changes in salinity due to climate warming.
Weizhen Zhang, Jianjun Wang, Yun Li, Chao Song, Yongqiang Zhou, Xianqiang Meng, Ruirui Chen   +6 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Decoupling enzyme catalysis from thermal denaturation [PDF]

, 2010
The equilibrium model (EM) (Daniel et al., 2001) postulates two forms of a folded enzyme, one catalytically active (Eact) and the other inactive (Einact), which interconvert via a fast thermal equilibrium (Keq) (Figure A). This model for enzyme catalysis
Easter, Ashley Davys
core  

Irrigation frequency and irrigation amount of micro-sprinkler irrigation mulched regulate N2O emission of tomato (Solanum lycopersicum) soil

Frontiers in Sustainable Food Systems
IntroductionThere is a limited amount of research available on how changes in soil hydrothermal cycles impact soil N2O emissions in greenhouses that use a tomato irrigation system with micro-sprinkler irrigation mulched (MSM).MethodsThis study examined ...
Haijian Yang, Mingzhi Zhang, Wenqian Wu, Na Xiao, Mengmeng Sun, Yuan Li   +5 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source