Results 81 to 90 of about 1,499,817 (257)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Early biofouling detection using extracellular enzyme activity A prototype explored

, 2019
Early biofouling detection using extracellular enzyme activity; A prototype ...
Khan, Babar
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular enzyme activities and enzyme ratios in different horizons in arctic soils.

, 2014
Left panel: Extracellular enzyme activities for the C-acquiring enzyme cellobiohydrolase (CBH), the N-acquiring enzyme leucine-amino-peptidase (LAP) and the oxidative enzyme phenoloxidase (POX).
Anna Knoltsch (547468), Tim Urich (49469), Andreas Richter (87142), Sandra Kienzl (547467), Jörg Schnecker (547460), Birgit Wild (305428), Florian Hofhansl (517079), Mounir Takriti (547472), Robert Mikutta (547470), Norman Gentsch (547464), Ricardo J. Eloy Alves (547461), Lucia Fuchslueger (547463), Olga Shibistova (305425), Hana Šantrůčková (547471), Nikolay Lashchinskiy (547469), Georg Weltin (547473), Georg Guggenberger (305432), Jiří Bárta (547462), Petr Čapek (2669128), Antje Gittel (547465), Angelika Hofer (547466)   +20 more
core   +1 more source

Cloning, expression and characterization of the endoglucanase gene from Bacillus subtilis UMC7 isolated from the gut of the indigenous termite Macrotermes malaccensis in Escherichia coli

Electronic Journal of Biotechnology, 2015
Background: Bacillus subtilis UMC7 isolated from the gut of termite Macrotermes malaccensis has the ability to secrete a significant amount of extracellular endoglucanase, with an enzyme activity of 0.12 ± 0.01 μmol/min/mL.
Kelvin Swee Chuan Wei, Teow Chong Teoh, Philip Koshy, Ismail Salmah, Arifin Zainudin   +4 more
doaj   +1 more source

The effect of fruit on the extracellular enzyme profiles of fungi

Annals of Agricultural and Environmental Medicine, 2020
In recent years, the number of diseases caused by fungal pathogens has increased significantly. Many species of fungi are pathogenic for plants, causing a threat to food production and to humans, and are among the causes of chronic diseases.The aim of the study is to determine the enzyme profiles of fungi, depending on the different types of fruit with
Ewelina Farian, Grażyna Cholewa, Alicja Cholewa, Magdalena Matczuk, Wójcik-Fatla Angelina   +4 more
openaire   +3 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Study on the Effects of Different Light Supply Modes on the Development and Extracellular Enzyme Activity of Ganoderma lucidum

Agriculture
Edible fungi have certain photo-sensitivity during the mushroom emergence stage, but there have been few relevant studies on the responses of Ganoderma lucidum to different light irradiation conditions.
Yihan Liu, Yuan Luo, Wenzhong Guo, Xin Zhang, Wengang Zheng, Xiaoli Chen   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Soil physicochemical properties, C pool characteristics, and extracellular enzyme activity as the succession progresses

Soil physicochemical properties, C pool characteristics, and extracellular enzyme activity as the succession ...
Pang, Yue
core   +1 more source