Results 11 to 20 of about 1,191,619 (293)

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D, Ahmed-Abdi, B, Denton, C, Lafyatis, R, Layne, MD, Nikitorowicz-Buniak, J, Ponticos, M, Shiwen, X, Smith, BD, Stratton, R, Suki, B, Takahashi, A   +11 more
core   +14 more sources

Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications [PDF]

, 2009
Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid.
A Bertuzzi, A Bertuzzi, A Iordan, A Masi De, A Tosin, AC Newby, Andrea Tosin, BS Winters, CJW Breward, CJW Breward, CJW Breward, D Ambrosi, D Ambrosi, D Ambrosi, D Ambrosi, E Behravesh, E Canetta, G Forgacs, GA Truskey, H Oxlund, HM Byrne, HM Byrne, HP Greenspan, IJ Rao, JD Humphrey, JD Humphrey, JP Iredale, L Graziano, L Preziosi, LA Liotta, Luigi Preziosi, M Chaplain, M Sun, PA DiMilla, PA DiMilla, PP Pujuguet, PRA Johnson, RP Araujo, RP Araujo, RP Araujo, RP Araujo, S Astanin, SJ Franks, SJ Franks, SJ Franks, SP Palecek, V Lanza, W Baumgartner, WY Gu, YC Fung   +49 more
core   +1 more source

Collagens - structure, function and biosynthesis. [PDF]

, 2003
The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions.
Aigner, T, Gelse, K, Poschl, E
core   +1 more source

Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain [PDF]

, 1999
Increasing evidence indicates that tissue transglutaminase (tTG) plays a role in the assembly and remodeling of extracellular matrices and promotes cell adhesion.
Aeschlimann, D, Cox, A, Gaudry, CA, Griffin, M, Smith, C, Verderio, E   +5 more
core   +1 more source

Modeling cell movement in anisotropic and heterogeneous network tissues [PDF]

, 2007
Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions ...
Chauviere, A., Hillen, T., Preziosi, Luigi   +2 more
core   +1 more source

Extracellular Matrix (ECM) [PDF]

, 2012
The region of space at the periphery of cyanobacterial cells is the interface between the environment and intracellular processes. This metaspace may include a structure appressed to the outer wall and membrane, such as an extracellular polysaccharide (EPS), a structural and/or physiological discontinuity in the control of flow metabolites, as well as ...
Helm R.F., Potts M.
openaire   +3 more sources

Nanopatterned acellular valve conduits drive the commitment of blood-derived multipotent cells [PDF]

, 2016
Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes.
Aguiari, Paola, Barbon, Silvia, Bertalot, Thomas, Conconi, MARIA TERESA, DI LIDDO, Rosa, Gandaglia, Alessandro, Gerosa, Gino, Iop, Laura, Mandoli, Amit, Parnigotto, PIER PAOLO, Schrenk, Sandra, Tasso, Alessia   +11 more
core   +2 more sources

Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice

Frontiers in Neuroscience, 2019
It is well-known that hyaluronic acid (HA) as a component of brain extracellular matrix (ECM) plays a pivotal role in the nervous system and is involved in synaptic plasticity changes in vascular cognitive impairment and dementia.
Alena Balashova, Vladimir Pershin, Vladimir Pershin, Olga Zaborskaya, Olga Zaborskaya, Natalia Tkachenko, Natalia Tkachenko, Andrey Mironov, Andrey Mironov, Evgeny Guryev, Evgeny Guryev, Leonid Kurbatov, Murat Gainullin, Murat Gainullin, Irina Mukhina, Irina Mukhina   +15 more
doaj   +1 more source

SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesis

Bone Reports, 2022
Loss-of-function mutations in SMAD3 cause Loeys-Dietz syndrome type 3 (LDS3), a rare autosomal-dominant connective tissue disorder characterized by vascular pathology and skeletal abnormalities.
Ahmed El-Gazzar, Heeseog Kang, Nadja Fratzl-Zelman, Emma Webb, Aileen M. Barnes, Milena Jovanovic, Sarju G. Mehta, Vipan Datta, Vrinda Saraff, Ryan K. Dale, Frank Rauch, Joan C. Marini, Wolfgang Högler   +12 more
doaj   +1 more source

Extracellular matrix: Forum introduction [PDF]

Reproductive Biology and Endocrinology, 2004
Carson Daniel D
doaj   +2 more sources