Results 11 to 20 of about 3,243,882 (355)

Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

Journal of Hematology & Oncology, 2022
Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to promote cancer cells proliferation, migration, invasion, angiogenesis and immune evasion.
Yangfu Jiang, Hongying Zhang, Jiao Wang, Yongliang Liu, T. Luo, H. Hua   +5 more
semanticscholar   +1 more source

Extracellular matrix [PDF]

FEBS Letters, 1990
A succinct overview of recent results on the biochemistry of extracellular matrix (ECM) is presented. The rapid expansion of this discipline over the best decades renders impossible to give an even approximately complete coverage of matrix biology. Some selected results concerning the four major families of macromolecules composing the ECM, that is ...
Labat-Robert, J., Bihari-Varga, M., Robert, L.   +2 more
openaire   +2 more sources

Extracellular matrix alterations in chronic ischemic cardiomyopathy revealed by quantitative proteomics. [PDF]

JCI Insight
Buck KM, Rogers HT, Gregorich ZR, Mann MW, Aballo TJ, Gao Z, Chapman EA, Perciaccante AJ, Price SJ, Lei I, Tang PC, Ge Y.   +11 more
europepmc   +3 more sources

The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review

Biomimetics, 2022
The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It is comprised of varying proteins, including collagens, elastin, and smaller quantities of structural proteins.
Robert B. Diller, A. Tabor
semanticscholar   +1 more source

Exposure to Bacteriophages T4 and M13 Increases Integrin Gene Expression and Impairs Migration of Human PC-3 Prostate Cancer Cells

Antibiotics, 2021
The interaction between bacteriophages and integrins has been reported in different cancer cell lines, and efforts have been undertaken to understand these interactions in tumor cells along with their possible role in gene alterations, with the aim to ...
Swapnil Ganesh Sanmukh, Nilton J. Santos, Caroline Nascimento Barquilha, Sérgio Alexandre Alcantara dos Santos, Bruno Oliveira Silva Duran, Flávia Karina Delella, Andrei Moroz, Luis Antonio Justulin, Hernandes F. Carvalho, Sérgio Luis Felisbino   +9 more
doaj   +1 more source

Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids

Nature Communications, 2022
Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin ...
Suran Kim, Sungjin Min, Yi Sun Choi, S. Jo, Jae Hun Jung, K. Han, Jin Kim, S. An, Yong Woo Ji, Yun-Gon Kim, Seung‐Woo Cho   +10 more
semanticscholar   +1 more source

Extracellular matrix and its therapeutic potential for cancer treatment

Signal Transduction and Targeted Therapy, 2021
The extracellular matrix (ECM) is one of the major components of tumors that plays multiple crucial roles, including mechanical support, modulation of the microenvironment, and a source of signaling molecules. The quantity and cross-linking status of ECM
Jiacheng Huang, Lele Zhang, Dalong Wan, Lin Zhou, Shusen Zheng, Shengzhang Lin, Yiting Qiao   +6 more
semanticscholar   +1 more source

Bacteriophages M13 and T4 Increase the Expression of Anchorage-Dependent Survival Pathway Genes and Down Regulate Androgen Receptor Expression in LNCaP Prostate Cell Line

Viruses, 2021
Wild-type or engineered bacteriophages have been reported as therapeutic agents in the treatment of several types of diseases, including cancer. They might be used either as naked phages or as carriers of antitumor molecules.
Swapnil Ganesh Sanmukh, Nilton José dos Santos, Caroline Nascimento Barquilha, Maira Smaniotto Cucielo, Márcio de Carvalho, Patricia Pintor dos Reis, Flávia Karina Delella, Hernandes F. Carvalho, Sérgio Luis Felisbino   +8 more
doaj   +1 more source

Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease

Frontiers in Aging, 2022
Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling
Tinka Vidović, Collin Y. Ewald
doaj   +1 more source

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Nature Communications, 2020
Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling.
Juliane Winkler, A. Abisoye-Ogunniyan, K. J. Metcalf, Z. Werb   +3 more
semanticscholar   +1 more source