Results 11 to 20 of about 1,191,682 (356)

Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease

Frontiers in Aging, 2022
Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling
Tinka Vidović, Collin Y. Ewald
doaj   +1 more source

A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: Cardiovascular diseases were defined as coronary artery, cerebrovascular, or peripheral arterial disease. Hyperhomocysteinemia (Hhcy) is an independent risk factor of cardiovascular diseases, including atherosclerosis.
Fouzia Zerrouk, Billel Chaouad, Adel Ghoul, Naima Chalour, Anissa Moulahoum, Zineb Khiari, Mohamed el Hadi Cherifi, Souhila Aouichat, Karim Houali, Yasmina Benazzoug   +9 more
doaj   +1 more source

Whole organism profiling of the Timp gene family

Matrix Biology Plus, 2023
Tissue inhibitor of metalloproteinases (TIMPs/Timps) are an endogenous family of widely expressed matrisome-associated proteins that were initially identified as inhibitors of matrix metalloproteinase activity (Metzincin family proteases).
David Peeney, Yu Fan, Sadeechya Gurung, Carolyn Lazaroff, Shashikala Ratnayake, Andrew Warner, Baktiar Karim, Daoud Meerzaman, William G. Stetler-Stevenson   +8 more
doaj   +1 more source

Longevity interventions temporally scale healthspan in Caenorhabditis elegans

iScience, 2022
Summary: Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population.
Cyril Statzer, Peter Reichert, Jürg Dual, Collin Y. Ewald   +3 more
doaj   +1 more source

Collagens - structure, function and biosynthesis. [PDF]

, 2003
The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions.
Aigner, T, Gelse, K, Poschl, E
core   +1 more source

Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications [PDF]

, 2009
Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid.
A Bertuzzi, A Bertuzzi, A Iordan, A Masi De, A Tosin, AC Newby, Andrea Tosin, BS Winters, CJW Breward, CJW Breward, CJW Breward, D Ambrosi, D Ambrosi, D Ambrosi, D Ambrosi, E Behravesh, E Canetta, G Forgacs, GA Truskey, H Oxlund, HM Byrne, HM Byrne, HP Greenspan, IJ Rao, JD Humphrey, JD Humphrey, JP Iredale, L Graziano, L Preziosi, LA Liotta, Luigi Preziosi, M Chaplain, M Sun, PA DiMilla, PA DiMilla, PP Pujuguet, PRA Johnson, RP Araujo, RP Araujo, RP Araujo, RP Araujo, S Astanin, SJ Franks, SJ Franks, SJ Franks, SP Palecek, V Lanza, W Baumgartner, WY Gu, YC Fung   +49 more
core   +1 more source

Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain [PDF]

, 1999
Increasing evidence indicates that tissue transglutaminase (tTG) plays a role in the assembly and remodeling of extracellular matrices and promotes cell adhesion.
Aeschlimann, D, Cox, A, Gaudry, CA, Griffin, M, Smith, C, Verderio, E   +5 more
core   +1 more source

MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation

Biology Open, 2017
Cell polarity has a fundamental role in shaping the morphology of cells and growing tissues. Polarity is commonly thought to be established in response to extracellular signals.
Artal Moreno-Fortuny, Laricia Bragg, Giulio Cossu, Urmas Roostalu   +3 more
doaj   +1 more source

Modeling cell movement in anisotropic and heterogeneous network tissues [PDF]

, 2007
Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions ...
Chauviere, A., Hillen, T., Preziosi, Luigi   +2 more
core   +1 more source

Dissecting the phenotypic variability of osteogenesis imperfecta

Disease Models & Mechanisms, 2022
Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1
Nadia Garibaldi, Roberta Besio, Raymond Dalgleish, Simona Villani, Aileen M. Barnes, Joan C. Marini, Antonella Forlino   +6 more
doaj   +1 more source