Results 11 to 20 of about 1,083,664 (336)

Extracellular matrix and schistosomiasis [PDF]

Memórias do Instituto Oswaldo Cruz, 1991
Zilton A. Andrade
openaire   +6 more sources

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

eLife, 2023
The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknown.
Elisabeth Jongsma, Anita Goyala, José Maria Mateos, Collin Yvès Ewald   +3 more
doaj   +1 more source

Exposure to Bacteriophages T4 and M13 Increases Integrin Gene Expression and Impairs Migration of Human PC-3 Prostate Cancer Cells

Antibiotics, 2021
The interaction between bacteriophages and integrins has been reported in different cancer cell lines, and efforts have been undertaken to understand these interactions in tumor cells along with their possible role in gene alterations, with the aim to ...
Swapnil Ganesh Sanmukh, Nilton J. Santos, Caroline Nascimento Barquilha, Sérgio Alexandre Alcantara dos Santos, Bruno Oliveira Silva Duran, Flávia Karina Delella, Andrei Moroz, Luis Antonio Justulin, Hernandes F. Carvalho, Sérgio Luis Felisbino   +9 more
doaj   +1 more source

Bacteriophages M13 and T4 Increase the Expression of Anchorage-Dependent Survival Pathway Genes and Down Regulate Androgen Receptor Expression in LNCaP Prostate Cell Line

Viruses, 2021
Wild-type or engineered bacteriophages have been reported as therapeutic agents in the treatment of several types of diseases, including cancer. They might be used either as naked phages or as carriers of antitumor molecules.
Swapnil Ganesh Sanmukh, Nilton José dos Santos, Caroline Nascimento Barquilha, Maira Smaniotto Cucielo, Márcio de Carvalho, Patricia Pintor dos Reis, Flávia Karina Delella, Hernandes F. Carvalho, Sérgio Luis Felisbino   +8 more
doaj   +1 more source

Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease

Frontiers in Aging, 2022
Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling
Tinka Vidović, Collin Y. Ewald
doaj   +1 more source

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D, Ahmed-Abdi, B, Denton, C, Lafyatis, R, Layne, MD, Nikitorowicz-Buniak, J, Ponticos, M, Shiwen, X, Smith, BD, Stratton, R, Suki, B, Takahashi, A   +11 more
core   +10 more sources

Dissecting the phenotypic variability of osteogenesis imperfecta

Disease Models & Mechanisms, 2022
Osteogenesis imperfecta (OI) is a heterogeneous family of collagen type I-related diseases characterized by bone fragility. OI is most commonly caused by single-nucleotide substitutions that replace glycine residues or exon splicing defects in the COL1A1
Nadia Garibaldi, Roberta Besio, Raymond Dalgleish, Simona Villani, Aileen M. Barnes, Joan C. Marini, Antonella Forlino   +6 more
doaj   +1 more source

Formation of atypical podosomes in extravillous trophoblasts regulates extracellular matrix degradation [PDF]

, 2012
Throughout pregnancy the cytotrophoblast, the stem cell of the placenta, gives rise to the differentiated forms of trophoblasts. The two main cell lineages are the syncytiotrophoblast and the invading extravillous trophoblast.
Alexander, Anand Patel, Artym, Ayling, Baldassarre, Barker, Behrendtsen, Bowden, Buccione, Buccione, Burgstaller, Calle, Cartwright, Cartwright, Cartwright, Chan, Destaing, Destaing, Goldman-Wohl, Harris, Harris, Isaka, Kam, Kaufmann, Kelley, LaMarca, Linder, Linder, Linder, Mueller, Nakahara, Philip R. Dash, Redondo-Munoz, Sabri, Sato, Weaver, Whitley, Xiao   +37 more
core   +2 more sources

MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation

Biology Open, 2017
Cell polarity has a fundamental role in shaping the morphology of cells and growing tissues. Polarity is commonly thought to be established in response to extracellular signals.
Artal Moreno-Fortuny, Laricia Bragg, Giulio Cossu, Urmas Roostalu   +3 more
doaj   +1 more source

Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications [PDF]

, 2009
Resorting to a multiphase modelling framework, tumours are described here as a mixture of tumour and host cells within a porous structure constituted by a remodelling extracellular matrix (ECM), which is wet by a physiological extracellular fluid.
A Bertuzzi, A Bertuzzi, A Iordan, A Masi De, A Tosin, AC Newby, Andrea Tosin, BS Winters, CJW Breward, CJW Breward, CJW Breward, D Ambrosi, D Ambrosi, D Ambrosi, D Ambrosi, E Behravesh, E Canetta, G Forgacs, GA Truskey, H Oxlund, HM Byrne, HM Byrne, HP Greenspan, IJ Rao, JD Humphrey, JD Humphrey, JP Iredale, L Graziano, L Preziosi, LA Liotta, Luigi Preziosi, M Chaplain, M Sun, PA DiMilla, PA DiMilla, PP Pujuguet, PRA Johnson, RP Araujo, RP Araujo, RP Araujo, RP Araujo, S Astanin, SJ Franks, SJ Franks, SJ Franks, SP Palecek, V Lanza, W Baumgartner, WY Gu, YC Fung   +49 more
core   +1 more source