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Extracellular Matrix (ECM) [PDF]

, 2012
The region of space at the periphery of cyanobacterial cells is the interface between the environment and intracellular processes. This metaspace may include a structure appressed to the outer wall and membrane, such as an extracellular polysaccharide (EPS), a structural and/or physiological discontinuity in the control of flow metabolites, as well as ...
Helm R.F., Potts M.
openaire   +3 more sources

Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix in vivo Can Induce Seizures in Neonatal Mice

Frontiers in Neuroscience, 2019
It is well-known that hyaluronic acid (HA) as a component of brain extracellular matrix (ECM) plays a pivotal role in the nervous system and is involved in synaptic plasticity changes in vascular cognitive impairment and dementia.
Alena Balashova, Vladimir Pershin, Vladimir Pershin, Olga Zaborskaya, Olga Zaborskaya, Natalia Tkachenko, Natalia Tkachenko, Andrey Mironov, Andrey Mironov, Evgeny Guryev, Evgeny Guryev, Leonid Kurbatov, Murat Gainullin, Murat Gainullin, Irina Mukhina, Irina Mukhina   +15 more
doaj   +1 more source

SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesis

Bone Reports, 2022
Loss-of-function mutations in SMAD3 cause Loeys-Dietz syndrome type 3 (LDS3), a rare autosomal-dominant connective tissue disorder characterized by vascular pathology and skeletal abnormalities.
Ahmed El-Gazzar, Heeseog Kang, Nadja Fratzl-Zelman, Emma Webb, Aileen M. Barnes, Milena Jovanovic, Sarju G. Mehta, Vipan Datta, Vrinda Saraff, Ryan K. Dale, Frank Rauch, Joan C. Marini, Wolfgang Högler   +12 more
doaj   +1 more source

Brain extracellular matrix [PDF]

Glycobiology, 1996
The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant.
openaire   +2 more sources

Extracellular matrix gene expression signatures as cell type and cell state identifiers

Matrix Biology Plus, 2021
Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher, Christian Feregrino, Patrick Tschopp, Collin Y. Ewald   +3 more
doaj   +1 more source

Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington’s disease

Scientific Reports, 2022
Currently, there are no therapies available to modify the disease progression of Huntington’s disease (HD). Recent clinical trial failures of antisense oligonucleotide candidates in HD have demonstrated the need for new therapeutic approaches.
Simon Marius Galyan, Collin Y. Ewald, Xavier Jalencas, Shyam Masrani, Selin Meral, Jordi Mestres   +5 more
doaj   +1 more source

Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia

Leukemia Research Reports, 2018
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been ...
Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi   +6 more
doaj   +1 more source

Decellularized Tissues for Wound Healing: Towards Closing the Gap Between Scaffold Design and Effective Extracellular Matrix Remodeling

Frontiers in Bioengineering and Biotechnology, 2022
The absence or damage of a tissue is the main cause of most acute or chronic diseases and are one of the appealing challenges that novel therapeutic alternatives have, in order to recover lost functions through tissue regeneration.
Víctor Alfonso Solarte David, Víctor Alfonso Solarte David, Viviana Raquel Güiza-Argüello, Martha L. Arango-Rodríguez, Claudia L. Sossa, Claudia L. Sossa, Silvia M. Becerra-Bayona   +6 more
doaj   +1 more source

Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling

Translational Oncology
Mounting evidence suggests that the tissue inhibitor of metalloproteinases-2 (TIMP2) can reduce tumor burden and metastasis. However, the demonstration of such anti-tumor activity and associated mechanisms using in vivo tumor models is lacking.
David Peeney, Sarvesh Kumar, Tej Pratap Singh, Yueqin Liu, Sandra M. Jensen, Ananda Chowdhury, Sasha Coates-Park, Joshua Rich, Sadeechya Gurung, Yu Fan, Daoud Meerzaman, William G. Stetler-Stevenson   +11 more
doaj   +1 more source

Extracellular Matrix of Echinoderms

Marine Drugs, 2023
This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko   +1 more
doaj   +1 more source