Results 71 to 80 of about 1,191,619 (293)

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin. [PDF]

, 2018
The extracellular matrix is a master regulator of tissue homeostasis in health and disease. Here we examined how the small, leucine-rich, extracellular matrix proteoglycan decorin regulates cardiomyocyte metabolism during fasting in vivo.
Gubbiotti, Maria A., Hoek, Jan B., Iozzo, Renato V., Rodeck, Ulrich, Seifert, Erin L.   +4 more
core   +1 more source

Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro. [PDF]

, 2016
Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease.
Bhutani, Srishti, Christman, Karen L, Davis, Michael E, Fierro, Marcos J, French, Kristin M, Ghosh-Choudhary, Shohini, Johnson, Todd D, Maxwell, Joshua T, Taylor, W Robert   +8 more
core   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer [PDF]

, 2008
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Biomacromolecules, copyright © American Chemical Society after peer review.
Angele P., Babensee J. E., Badylak S., Badylak S. F., Badylak S. F., Badylak S. F., Billiar K., Brody S., Burugapalli K., Buttafoco L., Chandrasekar D., Charulatha V., Chen R. R., Coburn J. C., Curotto E., Domanski D. M., Duan X., Duan X., Duan X., DuBay D. A., Dumas P., Ferrando J. M., Garcia Y., Grinnell F., Henry J. A., Hodde J., Hodde J. P., Ko R., Kochupura P. V., Koizumi N. J., Lee J. M., Lee S. H., Liang H. C., Ma L., Ma Z., Malafaya P. B., McDevitt C. A., McKegney M., Meinert M., Najlah M., Nourse A., Olde Damink L. H., Olde Damink L. H., Osborne C. S., Papagiannaros A., Pek Y. S., Pieper J. S., Saito H., Sokolsky-Papkov M., Tabata Y., Tessmar J. K., Unsworth J. M., van Wachem P. B., van Wachem P. B., van Wachem P. B., Voytik-Harbin S. L., Wissink M. J., Wissink M. J., Wolkers W. F., Yee N., Zhong S., Zilla P.   +61 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evidence that an RGD-dependent receptor mediates the binding of oligodendrocytes to a novel ligand in a glial-derived matrix. [PDF]

, 1988
A simple adhesion assay was used to measure the interaction between rat oligodendrocytes and various substrata, including a matrix secreted by glial cells. Oligodendrocytes bound to surfaces coated with fibronectin, vitronectin and a protein component of
Cardwell, MC, Rome, LH
core  

Hyperglycemia and Hyperlipidemia Act Synergistically to Induce Renal Disease in LDL Receptor-Deficient BALB Mice [PDF]

, 2004
Diabetic nephropathy is the leading cause of end-stage renal disease in Western countries, but only a portion of diabetic patients develop diabetic nephropathy.
Alpers, Charles E., Hudkins, Kelly L., Kirk, Elizabeth, LeBoeuf, Renée C., Mühlfeld, Anja S., Segerer, Stephan, Spencer, Min W.   +6 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix [PDF]

, 2015
Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and diseased tissues--particularly in development, wound healing, tissue regeneration and cancer--the mechanisms that direct the assembly and regulate hierarchical ...
Gourdon, Delphine, Klotzsch, Enrico, Kubow, Kristopher E., Luna, Sheila, Smith, Michael L., Vogel, Viola, Vukmirovic, Radmila, Zhe, Lin   +7 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source