Results 111 to 120 of about 2,138,893 (293)

Extracellular Matrix in Plants and Animals: Hooks and Locks for Viruses

Frontiers in Microbiology, 2017
The extracellular matrix (ECM) of animal and plants cells plays important roles in viral diseases. While in animal cells extracellular matrix components can be exploited by viruses for recognition, attachment and entry, the plant cell wall acts as a ...
Livia Stavolone, Livia Stavolone, Vincenzo Lionetti   +2 more
doaj   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Functional Differentiation of Type II and Type I Collagen Articular Models in Synovial Fluid Film Formation and Recombinant Equine Lubricin Retention

Advanced Functional Materials, EarlyView.
Collagen II coatings support the formation of synovial fluid nanofilms, while collagen I coatings do not. Both bind recombinant equine lubricin similarly. These findings may help explain articular cartilage surface joint dysfunction, inform biomaterial design for synovial joint repair, and expand on lubricin‐based osteoarthritis therapies.
Diego R. Jaramillo Pinto, Nicolas L. Mendoza, Syeda Tajin Ahmed, Yidan Wen, Lenka Vitkova, Spencer M. Witt, Kaleb A. Cutter, Ummay Honey, Matthew J. Paszek, Heidi L. Reesink, Lawrence J. Bonassar, Kevin De France, Roberto C. Andresen Eguiluz   +12 more
wiley   +1 more source

Alzheimer’s Tau seeds-induced pathology enhances hippocampal extracellular diffusion

Communications Biology
The extracellular space (ECS) is a complex, dynamic network occupying about 20% of the brain, filled with a cerebrospinal fluid-like solution rich in extracellular matrix (ECM) molecules.
Juan Estaún-Panzano, Anna Lovisotto, Claire Mazzocco, Carolina Piva, Morgane Darricau, Ivo Calaresu, Quentin Gresil, Vincent Planche, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard   +11 more
doaj   +1 more source

Fibrin and Collagen Differentially but Synergistically Regulate Sprout Angiogenesis of Human Dermal Microvascular Endothelial Cells in 3-Dimensional Matrix

International Journal of Cell Biology, 2013
Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins. Alteration of ECM composition and architecture is a hallmark feature of wound clot and tumor
Xiaodong Feng, Marcia G. Tonnesen, Shaker A. Mousa, Richard A. F. Clark   +3 more
doaj   +1 more source

Mechanical Programming of PEGDA‐β‐CD Polyrotaxane‐Based Hydrogels via Host–Guest Molecular Recognition

Advanced Functional Materials, EarlyView.
A mechanically programmable hydrogel for tissue engineering is developed by modulating the molecular threading density of poly(ethylene glycol) diacrylate‐β‐cyclodextrin (PEGDA‐β‐CD) polyrotaxane and combining it with β‐CD‐modified gelatin. The polyrotaxane‐guided transition from disordered pores to laminar microstructures enables precise tuning ...
Shiyi Chen, Xudan Xing, Haopu Su, Dominik Voll, Xiaohe Xu, Jiafeng Wan, Tongtong Cui, Christian W. Schmitt, Stefan Bräse, Peng Li, Patrick Théato   +10 more
wiley   +1 more source

Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo

Advanced Functional Materials, EarlyView.
In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim, Jeongah Shin, Chowon Kim, Honghwan Choi, Dahee Kim, Sungkyu Lee, Choongmo Kang, Hyunsik Hong, Taehoon Ha, Nayeon Kang, Jungyeon Rhi, Ramar Thangam, Yuri Kim, Jeongyun Heo, Cheol Hwan Kwak, Jangsun Hwang, Daun Jeong, Rasoul Moradi, Sunghoon Hur, Hyun‐Cheol Song, Hyun‐Do Jung, Min Jae Lee, Rongqin Huang, Pooyan Makvandi, Yun Suk Huh, Ji Hye Choi, Wenguo Cui, Sehoon Kim, Heemin Kang   +28 more
wiley   +1 more source

3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

Nature Communications, 2019
The brain extracellular matrix (ECM) is altered in brain tumors, but its role in cancer progression and drug sensitivity are difficult to study. Here the authors develop a 3D bioengineered brain tissue model using patient-derived samples and tunable ...
Disha Sood, Min Tang-Schomer, Dimitra Pouli, Craig Mizzoni, Nicole Raia, Albert Tai, Knarik Arkun, Julian Wu, Lauren D. Black, Bjorn Scheffler, Irene Georgakoudi, Dennis A. Steindler, David L. Kaplan   +12 more
doaj   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

MedComm
Extracellular matrix (ECM) is a dynamic, three‐dimensional network that provides structural support and regulates key biological processes, including cell adhesion, migration, differentiation, and signal transduction.
Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu   +11 more
doaj   +1 more source