Results 101 to 110 of about 2,138,893 (293)
Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R
, 2021 The brain extracellular matrix (ECM) consists of extremely long-lived proteins that assemble around neurons and synapses, to stabilize them. The ECM is thought to change only rarely, in relation to neuronal plasticity, through ECM proteolysis and renewed
Olsthoorn, Linda H. M. +10 more
core +1 more source
Fibroblast senescence-associated extracellular matrix promotes heterogeneous lung niche
APL BioengineeringSenescent cell accumulation in the pulmonary niche is associated with heightened susceptibility to age-related disease, tissue alterations, and ultimately a decline in lung function.
Andrew M. Howes +8 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Investigating the interplay between extracellular matrix and metabolic rewiring in sarcoma aggressiveness [PDF]
openThe extracellular matrix (ECM) is one of the major structural components of the tumour microenvironment, and it is mainly composed of collagen molecules.
SBUELZ, FRANCESCA
core
Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells [PDF]
, 2007 Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis. Studies have established a direct role for nitric oxide (NO) in the regulation of gene expression in mesangial cells.
Nelson, Peter J. +4 more
core +1 more source
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.This study explores the discrepancies between bulk mechanics and spatial mapping in a tissue‐mimetic hydrogel model. Microplastic particles create localized stiff mechanical microenvironments that are detectable by cellular‐scale nanoindentation but leave bulk properties unchanged as measured by rheology.
Ahron T. Verschleisser +3 more
wiley +1 more source
Sullivan, MillicentKiick, Kristi L.Despite the great potential of topically administered therapeutics in wound repair, due to the harsh wound environment, topically administered therapeutics are cleared out from the wound quickly, resulting in the ...
Hwang, Jeongmin
core +1 more source
Advanced Functional Materials, EarlyView.A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov +4 more
wiley +1 more source
Mathematical modelling of the loss of tissue compression responsiveness and its role in solid tumour development [PDF]
, 2005 This paper presents a mathematical model of normal and abnormal tissue growth. The modelling focuses on the potential role that stress responsiveness may play in causing proliferative disorders which are at the basis of the development of avascular ...
Preziosi, L. +8 more
core +1 more source